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Cell Biology / Development PhD Projects in Birmingham

We have 74 Cell Biology / Development PhD Projects in Birmingham

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Showing 1 to 10 of 74
  Understanding how tetraspanins and the ‘molecular scissor’ ADAM10 promote blood cancer
  Dr M Tomlinson, Dr F L Khanim
Application Deadline: 20 January 2019
Steve Briddon (University of Nottingham) 3rd supervisor. Nick Holliday (University of Nottingham) 4th supervisor. Introduction. T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive blood cancer that is in urgent need of more effective therapies.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Application Deadline: 20 January 2019
Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Dissecting the interplay between cardiomyocytes and fibroblasts using human stem cell models of disease
  Dr D Pavlovic, Prof C Denning
Application Deadline: 20 January 2019
Applications are invited for a fully-funded PhD Studentship starting in October 2019, under the guidance of Dr Davor Pavlovic (University of Birmingham) and Prof Chris Denning (University of Nottingham).
  Promoter regulation heterogeneity and stratification of colorectal cancer organoids
  Prof F Mueller, Dr D J Stekel, Dr A Beggs
Application Deadline: 20 January 2019
Developing tumours are composed of a mixture of clonal subpopulations, containing distinct patterns of mutations leading to distinct transcriptome features.
  Arrhythmogenic potential of titin truncating variants in atrial and ventricular cardiomyocytes
  Dr K Gehmlich, Prof C Denning, Prof P Kirchhof
Application Deadline: 20 January 2019
Aims. The aim of this project is to understand to role of titin truncating variants (TTNtv) in the development of atrial and ventricular arrhythmias.
  An organotypic model of the bone remodelling process
  Dr A Naylor, Dr L Grover
Application Deadline: 15 February 2019
Project Background. Maintenance of bone integrity is a key medical challenge, especially in our ageing population. Bone tissue is actively produced, remodelled and repaired throughout life and disruption of this process causes fragility and disability.
  Single cell resolution analysis of transcriptional regulation in development by 4D imaging
  Prof F Mueller, Dr J. S. Fossey
Application Deadline: 6 January 2019
Due to mutations in enhancers and promoters, leads to multifactorial and congenital disorders.
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Application Deadline: 6 January 2019
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  Determining the translational potential of the highly phosphorylated proto-oncogene PBF
  Dr V Smith
Applications accepted all year round
In order to translate the many molecular alterations now detectable in human tumours into effective clinical management we need to fully understand their impact on tumour biology.
  Integrating omics, imaging and informatics to develop physiology-based kinetic (PBK) models for perturbation biology in an invertebrate model species
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 6 January 2019
This exciting 4-year BBSRC iCASE PhD opportunity bridges the University of Birmingham’s (*) metabolomics team and Unilever’s Safety and Environmental Assurance Centre (SEAC), both having state-of-the-art facilities and renowned research programmes, thereby creating an excellent environment for this challenging yet impactful research project.
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