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Molecular Biology PhD Projects in Bristol

We have 11 Molecular Biology PhD Projects in Bristol

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  Data mining for microbial adaptation to climate change - MScR in Global Environmental Challenges
  Dr G Barker
Application Deadline: 1 August 2019
About the Project. Microbes are key members of nutrient and energy cycles in all global ecosystems. Whole meta genome DNA sequencing is increasingly used to characterise microbial ecosystems and vast amounts of data are deposited in the public domain every year.
  Novel anti-inflammatory mechanisms of cyclic-AMP in vascular smooth muscle cells
  Dr M Bond
Applications accepted all year round
A self-funded PhD studentship is available at the University of Bristol to study novel anti-inflammatory mechanisms of cyclic-AMP in vascular disease.
  Molecular mechanisms controlling cardiac fibroblast proliferation during cardiac fibrosis
  Dr M Bond
Applications accepted all year round
Applicants are invited for a new self-funded PhD studentship to study the molecular mechanisms of cardiac fibrosis. Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease.
  Actin-dependent mechanisms of chromosome segregation in mammalian eggs
  Dr B Mogessie
Applications accepted all year round
Every human life starts when an egg is fertilised by a sperm. Fertilisable eggs are produced from oocytes by a specialised form of cell division called meiosis (1).
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round
Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Adhesion Pathways in Extracellular Matrix Organisation
  Prof J Adams
Applications accepted all year round
The extracellular matrix (ECM) provides structural and mechanical support to tissues and modulates cell phenotype and behaviour in health and disease.
  Chromatin and maintenance of genome stability
  Dr A Chambers
Applications accepted all year round
Within eukaryotes, DNA is packaged into chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ~147 bp of DNA around an octamer of histones proteins.
  Elucidating the mechanism of SMC complexes
  Prof M Dillingham
Applications accepted all year round
The segregation of bacterial chromosomes is orchestrated by the co-ordinated actions of ParB and condensin [1]. ParB (also called Spo0J) is a site-specific DNA binding protein that binds at and around parS sequences near the origin of replication to form “ParB networks” which define the bacterial centromere [2].
  How does the one-humped Arabian camel survive in the desert without drinking?
  Prof D Murphy, Dr M Greenwood
Applications accepted all year round
Whilst water balance is aggressively defended in all mammals, this is all the more so in the one-humped Arabian camel, which has a remarkable capacity to thrive in the hot, arid conditions of the Arabian deserts (1), and to survive extended periods of dehydration (2).
  Understanding the role of the novel apelin receptor ligand apela in the regulation of neuroendocrine function.
  Dr A O'Carroll
Applications accepted all year round
The apelin receptor APJ (1) was first identified as an orphan GPCR, with closest identity to the angiotensin II receptor, type AT1a.
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