Applications are invited for 4-year PhD studentships funded by AstraZeneca and the Department of Pharmacology. The students will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists.
The central dogma of molecular biology states that genetically encoded information flows from DNA to mRNA to protein. The flow from DNA to mRNA occurs through a process called transcription and the flow from mRNA to protein through a process called translation.
Over the course of a long evolutionary history vector-borne pathogens have developed mechanisms to successfully disrupt natural defences in both their mammalian hosts and insect vectors in order to survive and establish infection.
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.