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Structural Biology PhD Projects in Cambridge

We have 13 Structural Biology PhD Projects in Cambridge

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Showing 1 to 10 of 13
  Structure and Function of Innate Immune Signalling in Mosquito Vectors
  Research Group: Dr M Gangloff
  Dr M Gangloff
Applications accepted all year round
Over the course of a long evolutionary history vector-borne pathogens have developed mechanisms to successfully disrupt natural defences in both their mammalian hosts and insect vectors in order to survive and establish infection.
  DNA damage response and neurodegenerative diseases
  Dr S Khoronenkova
Applications accepted all year round
Human cells repair thousands of DNA lesions daily. The majority of lesions arise from the intrinsic chemical instability of DNA and include single-strand breaks and base modifications.
  Mechanism of transmembrane receptor activation
  Dr M Hyvonen
Applications accepted all year round
Applications are invited for a PhD position, starting in October 2019, in the group Dr Marko Hyvonen at University of Cambridge (http://hyvonen.bioc.cam.ac.uk/) to study the mechanism of transmembrane signalling by TGFbeta family growth factors.
  Molecular mechanism of innate immunity mediated by the Toll/IL1 receptor signalling pathways.
  Prof N J Gay
Applications accepted all year round
This group participates in the Wellcome Trust 4 year PhD programme in Developmental biology., MRC and BBSRC Doctoral Training Programmes.
  Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins
  Dr H Mott
Applications accepted all year round
Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round
The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Understanding Zika virus pathogenesis in human neurons
  Dr N Irigoyen
Application Deadline: 3 January 2019
Increased global travel, urbanization and climate change have dramatically increased the likelihood of encounters with emerging and re-emerging viruses.
  Characterisation of the mechanism of norovirus VPg-dependent RNA synthesis.
  Prof I Goodfellow
Application Deadline: 3 January 2019
Noroviruses have an impact of >$60 billion pa, yet we have no vaccines or therapeutics. This project will use a combination of molecular and biochemical approaches to dissect norovirus VPg-primed RNA synthesis.
  Characterization of clonal evolution of T-cell lymphoma
  Prof M Q Du
Application Deadline: 3 January 2019
It has long been assumed that malignant T-cell lymphoma is a monoclonal disease. i.e. the tumour grows and expands from a single cell.
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