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University of Leeds Cell Biology / Development PhD Projects

We have 8 University of Leeds Cell Biology / Development PhD Projects

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  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round

Funding Type

PhD Type

We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Identifying cardiac disease markers using non-lethal ’biopsy’ of cells.
  Research Group: School of Biomedical Sciences
  Dr A.J. Smith
Applications accepted all year round

Funding Type

PhD Type

This project will build on our recent exciting discovery that a novel chemical tool, the polymer styrene maleic acid (SMA), can ‘biopsy’ human vascular cells, extracting proteins from the membrane without killing the cells.
  Characterisation of a pre-osteoblast subset of human mesenchymal stem cells: implications for novel osteoarthritis and osteoporosis treatment development
  Dr E Jones, Prof D McGonagle
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) and osteoporosis (OP) are the most common age-related skeletal diseases. They seriously affect patient’s quality of life and represent a significant healthcare burden to the UK society.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Understanding drug-resistance in myeloid cancer
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
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