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University of Manchester, Faculty of Biology, Medicine and Health PhD Projects

We have 160 University of Manchester, Faculty of Biology, Medicine and Health PhD Projects

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Showing 1 to 10 of 160
  (BBSCR DTP) Design of allosteric small molecule probes of fibrosis using molecular dynamics simulations
  Dr R A Bryce, Dr K Piper Hanley, Dr R Whitehead
Application Deadline: 31 January 2019
Integrins are a family of protein receptors that play a major role in cell survival, growth and migration. Their function is to transmit signals across the cell membrane by undergoing an elegant large scale structural rearrangement.
  (BBSRC DTP CASE) Anti-inflammatory microbes and their potential as topical therapeutics
  Prof C A O'Neill, Prof A McBain
Application Deadline: 31 January 2019
The epidermis of skin is the primary interface between the body and the outside world. As such, the epidermis is constantly under threat of dehydration as there is a permanent driving force for water to leave the skin to the external dry environment.
  (BBSRC DTP CASE) Applying – omics methods to map the circadian matrisome
  Dr J Swift, Dr Q-J Meng, Prof K E Kadler
Application Deadline: 31 January 2019
Circadian rhythm regulates and synchronises biological processes through a daily cycle. Molecular clocks in cells throughout the human body are entrained to a ‘master clock’ located in the hypothalamus, and cells in almost all tissues have been found to contain rhythmic genes.
  (BBSRC DTP CASE) Development of novel peptide hydrogel therapies for endometriosis and endometrial cancer
  Prof K Marshall, Prof A Miller, Dr D Fischer
Application Deadline: 31 January 2019
Background. Endometrial cancer and endometriosis are common gynaecological disorders, which arise from the uterine lining. Cancer develops by glandular cell differentiation, whilst implantation and growth of endometrial-like tissue in endometriosis induces a chronic inflammatory reaction causing pain and infertility.
  (BBSRC DTP CASE) Fostering the next generation of molecular diagnostics: 3D microfluidic RNA-sensing hydrogel biosensors for clinical analysis of miRNA biomarkers.
  Dr E Bichenkova, Prof A Saiani, Dr H Aojula
Application Deadline: 31 January 2019
This project will be carried out at the interface between academia and industry, in close collaboration with our industrial partner, Manchester BIOGEL Ltd, to facilitate translational development of a novel diagnostic platform by bridging the gap between a scientific discovery and its future commercialisation.
  (BBSRC DTP CASE) Understanding how macrophages restore immune health after infection
  Dr G Lopez-Castejon, Dr D Brough
Application Deadline: 31 January 2019
Inflammation is the response of the body to tissue danger.
  (BBSRC DTP) Mapping the structural and functional organisation of the human brain via in vivo neuroimaging and complex network analysis.
  Dr L Cloutman, Dr A Woollams
Application Deadline: 31 January 2019
The performance of the wide range of cognitive tasks we carry out in our daily lives including remembering, speaking, deciding and planning depends upon the interaction of complex networks of widely distributed brain regions.
  (BBSRC DTP) A new animal test of emotional cognition
  Dr J Gigg, Dr D Talmi, Prof J Neill
Application Deadline: 31 January 2019
This project will create and implement a new animal test for emotional biases in attention and memory that is more closely linked with the impact that emotion has on the same functions in humans.
  (BBSRC DTP) Are the pathways that protect tissues from mechanical stress lost in ageing?
  Dr J Swift, Dr S Richardson, Prof S Cartmell
Application Deadline: 31 January 2019
The defining qualities of our cells - their physical features and function - can be determined by their surroundings, but the tissue environment can be demanding.
  (BBSRC DTP) Cardiac Physiology in the World’s Oldest Vertebrate, The Greenland Shark
  Dr H Shiels, Dr G Galli, Dr A Stevens, Dr C Pinali
Application Deadline: 31 January 2019
The life span of the Greenland shark is at least 272 years and may be as long as 500 years making this animal the longest living vertebrate on the planet1.
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