We have 90 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships
The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships
We have 90 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships
Evaluation of MCT1s role in chromatin remodelling and metabolomics changes involved in cancer progression
Monocarboxylate transporter 1 (MCT1) is a transmembrane protein involved in cell metabolism and mediates transport of monocarboxylates (such as pyruvate and lactate) in both directions across plasma membrane. Read more
Discerning the role of metabolic proteins in nucleus
Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more
Unravelling complex somatic genomic variations: advancing early diagnostics and precision medicine
Complex somatic structural variations (SVs) in genomic regions such as centromeres and telomeres play a crucial role in driving many genetic disorders. Read more
Sunlight exposure and cutaneous production of vitamin D in Black African/Afro-Caribbean adults
Our main source of vitamin D is through skin exposure to ultraviolet radiation (UVR) in sunlight. Vitamin D is essential for healthy bones and is associated with reduced incidence of several cancers and immune-mediated disorders. Read more
(MB-PhD) In-depth omics profiling of the apical fallopian tube surface towards early
Ovarian cancer remains one of the deadliest gynaecological cancers, often diagnosed at advanced stages when treatment options are limited. Read more
(MB-PhD) Resistin: Leukaemia's Secret Weapon Against the Immune System
Cancer cells employ a variety of mechanisms to evade detection by the body’s immune system, enabling their own growth and survival. Read more
(MB-PhD)Immunomodulation in multiple myeloma
Multiple myeloma is a devastating B-cell malignancy for which there is no cure. The development of immunomodulatory drugs (IMiDs) has proved transformative to multiple myeloma care, however, their remain unanswered questions related to the mechanism of action of this important drug class. Read more
(MB-PhD) Smaller, Better, Faster, Stronger: real-time colorectal cancer management using nanopore sequencing.
Colorectal cancer (CRC) is ranking among the leading causes of cancer-related morbidity and mortality and where early onset is increasing. Read more
(MB-PhD) MYST Histone Acetyltransferases as Therapeutic Targets in Acute Myeloid Leukaemia
Cytotoxic chemotherapy has been the standard of care for treatment of acute myeloid leukaemia (AML) for the last 50 years. Unfortunately, more often than not, it fails to cure patients, and the 5 years survival rate for all-comers with AML is only around 20%. Read more
(MB-PhD) Multiomic investigation of drug resistance in lobular breast cancers
Lobular breast cancers represent one of the understudied cancers but of unmet need, due to their poor response to targeted therapies. Read more
(MB-PhD) Investigation of signalling from the microenvironment in metastasis of invasive lobular breast cancer
This project focuses on lobular breast cancer (LBC), a less-studied subtype of breast cancer constituting about 15% of diagnoses. Read more
(MB-PhD) Gene regulatory networks driving metastatic progression in oesophageal adenocarcinoma
Oesophageal adenocarcinoma (OAC) incidence is increasing and yet survival rates remain very poor. There are limited treatment options, especially for metastatic disease, which is especially problematic as patients usually present with late stage disease. Read more
Grief experiences of patients in a secure mental health inpatient hospital: exploring staff and patient perspectives
Although grief is a part of life, some experiences of grief can lead to a deterioration of mental health. A substantial body of research has been undertaken on grief and grief responses, but few studies have focused on the experiences of those bereaved in secure environments. Read more
Dissecting how innate immune heterogeneity controls health and disease
Inflammation is the response of our immune systems to danger. It is a beneficial host response coordinated largely innate immune cells such as macrophages. Read more