We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

Deafness and hearing loss combined is the most prevalent sensory deficit experienced by children. In England alone, more than 45000 children are deaf or have a hearing loss. Read more

Supervisors: Dr A Heinrich, Dr H Chilton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Diagnostics for FMF patients and carrier survival in pandemics

The University of Manchester Faculty of Biology, Medicine and Health

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Supervisors: Dr P Arkwright, Dr G Lopez-Castejon, Dr J Cavet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the mechanistic basis of Aspergillus fumigatus and Non-tuberculous mycobacteria coinfection

The University of Manchester Faculty of Biology, Medicine and Health

Respiratory infections caused by bacteria, fungi and viruses are a global cause of death according to the WHO. Respiratory coinfections are on the rise and in general linked with poor patient outcomes. Read more

Supervisors: Dr S Gago, Dr CK Kosmidis, Prof L Tabernero

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Inflammatory Arthritis in Childhood: Impact, Outcomes and Safety of Treatment

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile Idiopathic Arthritis is the most common inflammatory arthritis of childhood. Although less common than arthritis in adults, a diagnosis of arthritis in a child can have lasting impacts on that child and their families through their entire lifespan. Read more

Supervisors: Prof K Hyrich, Dr L Kearsley-Fleet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the factors that influence psychosocial functioning in older people with bipolar disorder

The University of Manchester Faculty of Biology, Medicine and Health

Bipolar disorder is classified as a lifelong, recurrent condition, associated with functional decline and a reduction in quality of life (Michalak et al., 2005; Bonnín et al., 2012). Older adults are estimated to represent approximately 25% of people diagnosed with bipolar disorder (Ljubic et al., 2021). Read more

Supervisors: Dr E.T Tyler, Dr K Berry, Dr J Palmier-Claus

Year round applications PhD Research Project Self-Funded PhD Students Only

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PBPK modelling of disease-drug interactions using transporter and enzyme biomarker data

The University of Manchester Faculty of Biology, Medicine and Health

Precision dosing strategies require accounting for between-patient variability in pharmacokinetics. Read more

Supervisors: Dr A Galetin, Dr Daniel Scotcher, Prof A Rostami

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of Human cytomegalovirus glycoprotein polymorphisms in disease pathogenesis

The University of Manchester Faculty of Biology, Medicine and Health

Human cytomegalovirus (HCMV) produces asymptomatic infection in most immunocompetent individuals but thereafter establishes life-long infection with periodic reactivation and asymptomatic shedding. Read more

Supervisors: Prof P Vallely, Prof P Klapper

Year round applications PhD Research Project Self-Funded PhD Students Only

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Evaluating the risk of biguanides and statins on cancer incidence and mortality rates: a mixed methods study combining pharmacoepidemiological and experimental approaches

The University of Manchester Faculty of Biology, Medicine and Health

In the UK, every two minutes someone is diagnosed with cancer and every four minutes someone dies from it– leading to more than 360,000 new cases and 160,000 deaths annually1. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines

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Defining the protective effects of a commensal bacterial strain in skin barrier function and protection from disease

The University of Manchester Faculty of Biology, Medicine and Health

Maintaining a healthy skin barrier is vital for our health. In response to skin wounding, we have a well-orchestrated immune response that heals the breach. Read more

Supervisors: Prof S Cruickshank, Prof A McBain, Dr R Unwin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of a decision tool for people offered bone conduction hearing implants

The University of Manchester Faculty of Biology, Medicine and Health

Background. Some people with hearing loss cannot wear conventional hearing aids and a bone conduction hearing implant (BCHI) might be considered. Read more

Supervisors: Dr RP Powell, Dr K Kluk, Dr S Peters, Mr KG Green, Dr PFH Feltham-Hill

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

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