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University of Birmingham Genetics PhD Projects

We have 26 University of Birmingham Genetics PhD Projects

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  Investigating the role of lysine methylation in the DNA damage response.
  Dr M Higgs
Applications accepted all year round

Funding Type

PhD Type

Our genomic DNA is under constant attack from DNA damaging agents, which are a continuing threat to genomic integrity. Defective resolution of DNA damage underlies several human diseases, including haematopoietic abnormalities and developmental disorders as well as cancer.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  The importance of the DNA damage response in neurodegeneration
  Dr R Tuxworth
Applications accepted all year round

Funding Type

PhD Type

DNA damage occurs in early-stage neurodegenerative diseases. The response of neurons to the damage may contribute to disease progression by inducing senescence, cell-cycle and apoptosis.
  Analysing immune responses to metastatic ovarian tumours to identify therapeutic targets
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Investigating how ovarian tumours avoid immune responses in cancer patients
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Identification of novel regulators of pancreatic beta-cell identity
  Dr I Akerman
Application Deadline: 31 October 2019

Funding Type

PhD Type

Diabetes is the largest epidemic in human history that affects 1 in 12 adults worldwide. Due to our modern lifestyle, it is one of the few diseases where the incidence is set to rise dramatically, with projections putting 650 million people at risk by 2040.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Elucidating the emergence of multi-drug resistant Enterococcus faecium
  Prof W Van Schaik, Dr A McNally
Applications accepted all year round

Funding Type

PhD Type

The Gram-positive bacterium Enterococcus faecium is a commensal of the intestinal tract of humans and animals. However, over the last two decades a clone of E.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
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