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Immunology PhD Projects

We have 120 Immunology PhD Projects

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Showing 41 to 50 of 120
  How an IFNγ target gene mediates resistance to immunotherapy
  Dr A Hurlstone, Prof K Williams, Dr J Bruce
Applications accepted all year round

Funding Type

PhD Type

Metastatic melanoma, a highly aggressive form of skin cancer, can respond well to immunotherapy with immune checkpoint inhibitors, but there are still a significant proportion of patients not benefitting or for whom benefits are not durable.
  How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
  Dr K Couper, Prof R K Grencis
Applications accepted all year round

Funding Type

PhD Type

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Regulation of intestinal immune responses to commensal bacteria by innate lymphoid cells
  Dr M Hepworth, Prof K Else
Applications accepted all year round

Funding Type

PhD Type

Commensal bacteria present in the gastrointestinal tract provide beneficial roles for the host, such as supporting nutrient metabolism.
  The nanoscale organisation of immune cell surfaces in health and disease
  Prof D Davis
Applications accepted all year round

Funding Type

PhD Type

Super-resolution microscopes, celebrated in the 2014 Nobel Prize for Chemistry, are one of the tools that allow us to study immune cells in unprecedented detail.
  Ultrastructural analysis of the mouse whipworm as a model for human trichuriasis
  Prof R K Grencis, Dr T Starborg
Applications accepted all year round

Funding Type

PhD Type

Gastrointestinal dwelling nematode parasites are extremely successful parasites of both man and animals infecting over a billion people worldwide and are responsible for considerable morbidity and ill health worldwide.
  Using statistical and functional analysis to investigate the contrasting disease specific roles of IL6R and the chr17q12 locus in the development of rheumatoid arthritis and asthma
  Dr J Curtin, Prof A Simpson
Applications accepted all year round

Funding Type

PhD Type

The Arthritis Research UK and Respiratory Centres at the University of Manchester have extensive research programmes investigating the genetic components of rheumatoid arthritis (RA) and asthma.
  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
  Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof M White, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.
  Exploring the influence of proteogenomics in patients receiving biologic drugs for treatment of psoriatic arthritis
  Prof A Barton, Dr James Bluett, Dr N Nair
Applications accepted all year round

Funding Type

PhD Type

Background. Psoriatic arthritis (PsA) is an inflammatory arthritis, associated with the chronic skin condition psoriasis, which causes joint inflammation.
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