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We have 246 PhD Research Projects PhD Projects, Programmes & Scholarships in Leeds

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PhD Research Projects PhD Projects, Programmes & Scholarships in Leeds

We have 246 PhD Research Projects PhD Projects, Programmes & Scholarships in Leeds

Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

  Research Group: Institute of Cancer Therapeutics
Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more

Evaluation of properties of wood pellets for Bioenergy and Carbon Capture and Storage Application

The current state of the art for utilisation of wood pellets is co-firing and the co-generation of biomass combustion products. The safe and effective storage, transportation and processing of wood pellets is then highly important for bioenergy applications. Read more

ERK5 MAPK signalling in Alzheimer’s disease

  Research Group: Pharmacology and Experimental Therapeutics
Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Directed Co-Crystallisation of Pharmaceuticals: developing a predictive method for co-crystallisation

  Research Group: Chemistry and Biosciences
In this project, we propose to use a combination of computational and experimental techniques to develop a predictive method for co-crystallisation. Read more

Development of novel materials for acoustic, thermal and vibration applications

  Research Group: Centre For Sustainable Environments
One of the main environmental problems of our time is elastomeric waste pollution. Due to mismanagement or inadequate recycling practices, up to 300 million tons of elastomeric waste ends up annually in landfill, or are discharged into ecosystems, posing potential threats to aquatic and terrestrial life. Read more

Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives

  Research Group: Institute of Cancer Therapeutics
Diseases affecting the bowel such as colorectal cancer (CRC) and the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease are major global healthcare challenges in the 21st century. Read more

Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more

Development of antibody-drug conjugates (ADCs) for oncology indications

  Research Group: Institute of Cancer Therapeutics
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. Read more

Development of a personalized therapy for pulmonary arterial hypertension (PAH)

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

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