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Biotechnology PhD Projects in Leeds

We have 10 Biotechnology PhD Projects in Leeds

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  Nanoscale Tweezers for single molecule manipulation
  Dr P Actis
Application Deadline: 1 February 2019
Are you interested in working at the interface between electronic engineering, physics, and biology? Do you want to contribute to the development of the next generation of ultra-sensitive tools for personalized health?.
  MRC DiMeN Doctoral Training Partnership: Addressing antimicrobial resistance (AMR): Affimers as therapeutic candidates and tools in antibacterial drug discovery
  Dr A O'Neill, Dr D Tomlinson
Application Deadline: 21 January 2019
The World Health Organization (WHO) has declared antimicrobial drug resistance (AMR) one of the greatest threats to human health, and it is predicted that this phenomenon will kill 10 million people annually by 2050 if not addressed.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round
Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Developing a tissue engineered/polyurethane blood vessel using bioengineering techniques
  Research Group: Chemistry and Biosciences
  Prof S Rimmer, Prof A M Graham, Dr K Riches-Suman
Applications accepted all year round
Vein graft failure is a significant issue in cardiovascular disease patients, with restenosis caused by alterations in flow patterns leading to remodelling and disease progression.
  Naked mole rat skin as a model for ageing and cancer resistance
  Research Group: Centre for Skin Sciences
  Prof V Botchkarev, Dr A Mardaryev, Dr N Botchkareva
Applications accepted all year round
The dramatic increase in the size of the elderly population in the UK and other developed countries results in the increased risk of age-related pathologies, including cancer and chronic wounds, and, therefore, is associated with clinical and socio-economic burdens.
  MRC DiMeN Doctoral Training Partnership: Development of deubiquitylase (DUB) inhibitors to target interferon-mediated diseases
  Dr E Zeqiraj, Dr F Del Galdo, Dr E Vital
Application Deadline: 21 January 2019
We are excited to offer a PhD studentship to study deubiquitylating (DUB) enzyme inhibitors and their potential as therapeutics for interferon-mediated diseases.
  MRC DiMeN Doctoral Training Partnership: Breaking up the fight: Defining the spatial requirements for therapeutic modulation of signalling through FcγRIIa
  Dr j Robinson, Prof A Morgan, Prof A Goldman, Dr M E Webb
Application Deadline: 21 January 2019
Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round
We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
  Understanding cancer using novel Affimer binding proteins
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr D Tomlinson
Applications accepted all year round
The specificity of protein-protein interactions is key to the successful execution of virtually every biological process yet molecular biology tools to block these interactions are lacking.
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