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Genetics PhD Projects in Leeds

We have 51 Genetics PhD Projects in Leeds

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Showing 1 to 10 of 51
  Understanding marine predator habitat use in the Mediterranean through eDNA
  Research Group: School of Biology
  Dr S Goodman, Dr E Valsecchi
Application Deadline: 7 January 2019
Overview. Understanding how animals use their habitats in relation to environmental and ecological factors is fundamental to basic ecological studies, evaluating potential exposure to impacts from human activities, and assessing species vulnerability to climate and ecosystem change.
  Understanding drug-resistance in myeloid cancer
  Dr P Laslo
Applications accepted all year round
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  Role of hypoxia in promotion of higher grade glioblastoma
  Research Group: Institute of Cancer Therapeutics
  Dr V Vinader, Dr K Afarinkia
Applications accepted all year round
Glioblastomas are categorized into four grades. Grade I is essentially benign and slow growing, and most amenable to treatment. Grade II tumors are larger and invade surrounding tissue.
  The effect of polysialyltransferase modulation on tumour cell migration
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr R Falconer
Applications accepted all year round
One of the main reasons for failure of cancer therapy today is an inability to control tumour dissemination, with secondary tumour deposits the cause of morbidity.
  The role of tumour microenvironment interactions in melanoma therapy resistance
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake, Dr M Sutherland
Applications accepted all year round
The incidence of malignant melanoma has steadily increased over the past 30 years, and it is predicted that 76,250 new cases will be diagnosed in the US and over 10,000 in the UK this year.
  Synthesis and Characterisation of Proteolysis targeting chimeras (PROTACs), potential anticancer agents
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules consisting of a small molecule which binds a desired protein target, a linker, and a ligand which binds to an E3 ubiquitin ligase.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round
Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev
Applications accepted all year round
Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction (Fig.
  Cytochromes P450 in Cancer: Opportunities for Development of Personalised Medicine - Project 1
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof P Loadman
Applications accepted all year round
The improved understanding of cancer biology provides opportunities for the development of molecular targeted therapies.
  Investigating how platelet-derived ncRNAs are altering the genetics of breast cancer cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Boyne, Prof P Loadman
Applications accepted all year round
Platelet-derived microparticles (PMPs) are capable of delivering non-coding RNAs (ncRNAs) to cells that modulate gene expression.
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