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Molecular Biology PhD Research Projects in Leeds

We have 20 Molecular Biology PhD Research Projects in Leeds

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Leeds  United Kingdom

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We have 20 Molecular Biology PhD Research Projects in Leeds

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Cell Biology: Exploring the mitotic functions of ASPM in human brain size regulation

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation. Read more

Accurate and Ultra-Sensitive DNA Mutation Detection by Nanopore Barcode Recording

Mutations of DNA within the genome are defining features of cancers, yet their accurate, quantitative, multiplexed detection with amplification-based methods is only possible above a threshold of tumour burden where sufficient material is available. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Cancer: Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC). Read more

Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Health Opportunity for Patient Empowerment in Gestational Diabetes (HOPE-GDM)

  Research Group: Chemistry and Biosciences
Gestational Diabetes is a temporary condition diagnosed at 24-28 weeks gestation, where the body is unable to maintain normal blood glucose levels due to insulin resistance during pregnancy. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

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