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Bioinformatics PhD Projects in Leicester

We have 12 Bioinformatics PhD Projects in Leicester

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Showing 1 to 10 of 12
  Harnessing large-scale genomic sequencing data to understand smoking behaviour
  Dr C Batini
Applications accepted all year round
In 2018 it has been announced that both whole exome sequences and whole genome sequences will be analysed in the 500K individuals in UK Biobank over the next two to five years.
  Genetic variants associated with multiple diseases
  Prof M Tobin
Applications accepted all year round
As increasing numbers of genetic associations are discovered, it is becoming clear that some genetic variants are associated with more than one or human phenotype (including disease phenotypes).
  Exploring the boundaries of the human acetylome
  Dr S Cowley, Prof D Panne
Application Deadline: 6 January 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
  New ways to look at enzyme structures
  Dr P C E Moody, Dr J Basran
Application Deadline: 6 January 2019
Metal-catalysed activation of oxygen in biology is achieved using either copper or iron. In the case of iron, this includes the heme-containing enzymes which activate oxygen.
  Vibriophages: saviour or sinner in aquaculture
  Dr A Millard, Prof M Clokie
Application Deadline: 6 January 2019
Vibrios are a diverse genera of Gram-negative bacteria that are widespread in the marine environment. The most well-known Vibrio species is Vibrio cholerae, as the causative agent of cholera.
  Clock gene polymorphisms in Drosophila; natural selection and function
  Prof C P Kyriacou, Dr E Rosato
Application Deadline: 6 January 2019
The molecular function of circadian clock genes are well understood and conserved from flies to mammals, but the implications of natural variation in clock gene sequences are only recently becoming evident.
  Investigating novel treatments for sepsis by understanding the pathogenesis of invasive infection
  Prof M Oggioni, Dr C D Bayliss
Application Deadline: 6 January 2019
We have recently discovered that bacteria, previously considered extracellular pathogens replicate within a subset of macrophages before causing invasive infection (Ercoli et al., Nature Microbiology 2018).
  Network interactions shape the circadian clock in Drosophila melanogaster
  Dr E Rosato, Prof C P Kyriacou
Application Deadline: 6 January 2019
The circadian clock is an endogenous mechanism that synchronizes almost all behaviour and physiology with the Earth’s 24 hour environmental cycles.
  Computational approaches to identifying biomarkers and therapeutics for human aging - Ref: ASUF2518
  Prof A Stolzing
Applications accepted all year round
Loughborough University in partnership with BioAge Labs is offering an industry PhD position under the supervision of Prof. Alexandra Stolzing.
  Using state-of-the-art proteomics to study the cellular and extracellular protein composition in human kidney disease; identification of novel biomarkers and bioactive drug targets in IgA Nephropathy
  Dr A Didangelos, Prof J Barratt
Applications accepted all year round
One of the key pathological characteristics of IgA nephropathy (IgAN) is the maladaptive and chronic accumulation and remodelling of the extracellular matrix (ECM) in affected glomeruli leading to fibrosis and progressive loss of function.
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