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Immunology PhD Projects in Leicester

We have 8 Immunology PhD Projects in Leicester

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  Impact of hypermutable sequences on microbial elicitation and evasion of host immune responses
  Dr C D Bayliss
Application Deadline: 6 May 2019
Non-typeable Haemophilus influenzae (NTHi) cause multiple human diseases including otitis media, the commonest bacterial infection in children.
  Understanding the role of serotonergic systems in motor control
  Dr J McDearmid, Dr W NORTON
Application Deadline: 5 May 2019
Serotonin is a key modulator of locomotor activity in the brain and spinal cord of vertebrates. A wide range pharmacological and lesion studies have provided important information about the role of serotonergic systems in modulation of motor output.
  Ameliorating ageing and age-related diseases by targeting senescent cells
  Dr S Macip, Dr S Cowley
Application Deadline: 5 May 2019
Ageing is a process defined by the accumulation of old (senescent) cells in tissues. It has been shown that senescent cells interfere with the normal functions of organs and thus lead to the normal phenotypic changes associated with ageing as well as the establishment of age-related diseases.
  Characterising Clostridium difficile defence strategies against bacteriophages
  Prof M Clokie, Dr A Millard
Application Deadline: 5 May 2019
Healthcare associated infections are a major problem for patients and a global health challenge. Clostridium difficile infection (CDI) is particularly problematic, for example the UK has ~20,000 infectious diarrhoeal cases every year, and progressive complications can lead to death in ~3% of infected patients.
  How do antibiotic-producing bacteria decide when to synthesise antibiotics, and how much to make?
  Dr H O'Hare, Dr G Mukamolova
Application Deadline: 5 May 2019
Actinobacteria are well-known as producers of bioactive secondary metabolites including antibiotics, insecticides and immunosuppressants.
  Serine/threonine protein kinase mediated regulation of protein secretion in mycobacteria
  Dr G Mukamolova, Dr H O'Hare
Application Deadline: 5 May 2019
Tuberculosis remains a major global threat as it affects humans and production animals. Mycobacterium tuberculosis and Mycobacterium bovis, the causative agents of tuberculosis in human and animals, are highly successful pathogens which secrete multiple virulence factors.
  Developing a model of secondary IgA nephropathy
  Dr C Stover, Prof J Barratt
Applications accepted all year round
Complement is a key humoral effector system when immune complexes are formed. On activation, split products are formed which attract inflammatory cells and enhance cellular responses.
  The role of complement properdin in bone biology
  Dr C Stover, Prof J Barratt
Applications accepted all year round
Bone mineral density is routinely measured in those at risk of developing osteoporosis and in those on various treatments, and informs the management of a growing proportion of the population.
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