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Molecular Biology PhD Projects in Leicester

We have 30 Molecular Biology PhD Projects in Leicester

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  Influence of a dietary supplement on blood and muscle oxidative stress biomarkers, skeletal muscle respiration and exercise performance in healthy adults
  Dr S Bailey, Dr NC Bishop, Dr N Martin
Application Deadline: 3 May 2020
This project will assess the efficacy of a dietary supplement to alter endogenous antioxidant systems, oxidative stress biomarkers and cellular respiration in human primary myoblasts and skeletal muscle sampled from humans undergoing dietary supplementation.
  Identifying novel therapies to prevent myocardial injury in type-2-diabetes
  Prof A Ng, Dr M Madhani, Prof W Dunn
Application Deadline: 6 May 2019
Type-2-diabetes (T2D) is a global epidemic associated with a major risk factor for coronary artery disease. Patients with T2D undergoing coronary artery bypass grafting (CABG) surgery have increased morbidity and mortality following cardiac surgery when compared to non-diabetic CABG patients.
  A real-time molecular epidemiological investigation into the contribution of fungal spores to seasonal asthma spikes
  Prof A Hansell, Dr C Pashley, Dr E Marczylo, Prof A Elliot
Application Deadline: 24 April 2019
This is a Medical Research Council (MRC) Toxicology Unit Integrative Toxicology Training Partnership (ITTP) Capacity Building studentship.
  Clock gene polymorphisms in Drosophila; natural selection and function
  Prof C P Kyriacou, Dr E Rosato
Application Deadline: 5 May 2019
The molecular function of circadian clock genes are well understood and conserved from flies to mammals, but the implications of natural variation in clock gene sequences are only recently becoming evident.
  Heme regulation of signalling at potassium channels in the cardiovascular system
  Dr N Storey, Dr N W Davies
Application Deadline: 5 May 2019
Ion channels in the smooth muscle of the cardiovascular system control blood pressure and cardiac contractility through changes in their membrane potential.
  Molecular mechanisms underpinning EML4 driven microtubule stabilization and cell migration
  Prof A M Fry, Prof K Brown
Application Deadline: 5 May 2019
EML4 is a poorly characterised microtubule-associated protein [1]. The purpose of this cell biology-focused PhD project is to explore the molecular mechanisms through which EML4 regulates microtubule dynamics and cell migration.
  How does nucleosome remodelling silence chromatin?
  Dr T Schalch, Dr S Cowley
Application Deadline: 5 May 2019
Regulation of transcription through chromatin architecture is governed by nucleosome remodelers and is essential in establishing the transcriptional programs of eukaryotic cells, which underpin survival, cellular identity and many disease states.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 5 May 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
  Exploring the boundaries of the human acetylome
  Dr S Cowley, Prof D Panne
Application Deadline: 5 May 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
  Obtaining mechanistic insights into interplay of multiple RAS effectors in a model system
  Dr K Tanaka, Dr C Dominguez
Application Deadline: 5 May 2019
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. Importantly, about 20% of all human cancers harbour mutations in RAS genes (COSMIC).
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