Identifying novel therapies to prevent myocardial injury in type-2-diabetes
Prof A Ng, Dr M Madhani, Prof W Dunn
6 May 2019
Type-2-diabetes (T2D) is a global epidemic associated with a major risk factor for coronary artery disease. Patients with T2D undergoing coronary artery bypass grafting (CABG) surgery have increased morbidity and mortality following cardiac surgery when compared to non-diabetic CABG patients.
How does nucleosome remodelling silence chromatin?
Dr T Schalch, Dr S Cowley
5 May 2019
Regulation of transcription through chromatin architecture is governed by nucleosome remodelers and is essential in establishing the transcriptional programs of eukaryotic cells, which underpin survival, cellular identity and many disease states.
Exploring the boundaries of the human acetylome
Dr S Cowley, Prof D Panne
5 May 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.