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We have 16 Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

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Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

We have 16 Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

University of Liverpool

We are curious problem solvers at the forefront of world-leading research. A hotbed of discovery and innovation, we're committed to addressing some of the toughest challenges in our society, both now and in the future. Join us in the search for answers by pursuing your PhD at the Original Redbrick.

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Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 12%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more
 Supervisor: Prof E Costello
 23 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Biological pathways supporting the formation and function of chromatin (Scholarship)

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more
 Supervisor: Dr CM Hammond
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating how tumour associated macrophages affect cancer metastasis and response to therapies

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Solid tumours are generally highly infiltrated by macrophages. Macrophages are heterogeneous and different populations with different and sometimes even opposite functions co-exist in tumours affecting cancer progression. Read more
 Supervisors: Dr A Mieglo, Prof M Schmid
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more
 Supervisor: Dr T You
 1 August 2024  PhD Research Project  Self-Funded PhD Students Only
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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more
 Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn
 1 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Exploring the roles of dynamic atypical protein phosphorylation in cancer

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Proteins are extensively regulated by dynamic, often reversible post-translational modifications (PTMs). This process allows cells to respond rapidly to environmental factors, be that e.g. Read more
 Supervisors: Prof C E Eyers, Prof A Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Why do cancers cells re-express meiotic SYCP1 protein?

University of Liverpool Institute of Systems, Molecular and Integrative Biology
The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Read more
 Supervisor: Dr U McClurg
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
 Supervisor: Dr MM Merino
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating local invasion in primary and secondary brain tumours

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Brain tumours are highly invasive and carry a poor prognosis. Secondary brain tumours or brain metastases (BM) are the most common tumours found in the brain affecting up to one third of patients with solid organ cancer. Read more
 Supervisor: Dr RZ Zakaria
 2 December 2024  PhD Research Project  Self-Funded PhD Students Only
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Understanding immune recognition in oral premalignant disorders (OPMDs)

University of Liverpool Department of Cellular and Molecular Physiology
Oral potentially malignant disorders (OPMD) are associated with an increased risk of transformation to oral squamous cell carcinoma (OSCC). Read more
 Supervisors: Prof K Hunter, Prof NS Savelyeva, Prof C Ottensmeier, Prof RS Shaw
 26 April 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
 Supervisor: Dr EG Laird
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Analysing the role of statins in cardiovascular protection

University of Liverpool Department of Pharmacology and Therapeutics
Drug-induced cardiovascular toxicity is a major problem affecting a number of cancer chemotherapy drugs (Cross et al., 2015). Read more
 Supervisors: Dr M Cross, Dr B Wilm, Dr AM Mondru
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Hepatic Models to personalise cancer chemotherapy

University of Liverpool Department of Pharmacology and Therapeutics
The most commonly used chemotherapy regimens for colorectal cancer with liver metastases are oxaliplatin combined with 5-FU and leucovorin, i.e. Read more
 Supervisors: Prof C Goldring, Dr A Chadwick, Prof IC Copple, Dr S Pushpakom
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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