Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

We have 136 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

The role of Human cytomegalovirus glycoprotein polymorphisms in disease pathogenesis

The University of Manchester Faculty of Biology, Medicine and Health

Human cytomegalovirus (HCMV) produces asymptomatic infection in most immunocompetent individuals but thereafter establishes life-long infection with periodic reactivation and asymptomatic shedding. Read more

Supervisors: Prof P Vallely, Prof P Klapper

Year round applications PhD Research Project Self-Funded PhD Students Only

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Evaluating the risk of biguanides and statins on cancer incidence and mortality rates: a mixed methods study combining pharmacoepidemiological and experimental approaches

The University of Manchester Faculty of Biology, Medicine and Health

In the UK, every two minutes someone is diagnosed with cancer and every four minutes someone dies from it– leading to more than 360,000 new cases and 160,000 deaths annually1. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of regulatory evolution in phage ecology

The University of Manchester Faculty of Biology, Medicine and Health

The regulation of genes crucially determines the fitness and function of all organisms. This is particularly relevant for bacteriophages, the viruses that infect bacteria, as they rely on a tightly scheduled program for a successful infection. Read more

Supervisors: Dr M Lagator, Dr CI Igler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cell-matrix interface engineering for regenerative medicine applications and disease modelling

The University of Manchester Faculty of Biology, Medicine and Health

Dr. Mahetab Amer is seeking motivated students with backgrounds in tissue engineering, cell biology, materials science, or related fields to join her dynamic, multidisciplinary research group at the Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester. Read more

Supervisor: Dr M.A Amer

Year round applications PhD Research Project Self-Funded PhD Students Only

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Optimizing phage-antibiotic-synergies to kill bacterial pathogens

The University of Manchester Faculty of Biology, Medicine and Health

Phage therapy, the use of viruses that only infect bacterial cells and kill them, is a promising potential solution to the antimicrobial resistance crisis that is threatening modern medicine1. Read more

Supervisors: Prof M Brockhurst, Dr CI Igler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive

Year round applications PhD Research Project Self-Funded PhD Students Only

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Inducing ferroptotic death to kill cancer cells

The University of Manchester Faculty of Biology, Medicine and Health

Ferroptosis is an iron-dependent form of regulated necrotic cell death triggered by oxidative degradation of lipids in membrane bilayers and subsequent irreparable damages to the plasma membrane (1). Read more

Supervisors: Dr C Tournier, Dr K Finegan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Full exploitation of amyloid PET-MR data for dementia research

The University of Manchester Faculty of Biology, Medicine and Health

Simultaneous PET-MR data acquisition using amyloid radiotracers has utility for future clinical studies such as the development of novel therapeutic interventions for dementia. Read more

Supervisors: Dr M Asselin, Dr J Matthews, Dr L Parkes

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 136 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

We have 136 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

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