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Medicine PhD Research Projects

We have 218 Medicine PhD Research Projects






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We have 218 Medicine PhD Research Projects

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Probing the tumour microenvironment in vivo with ultra-strong gradient MRI

This PhD project, sponsored by GlaxoSmithKline,  is well suited to students who would like to combine their knowledge of programming, computational modelling, physics and mathematics to better understand the structural changes in biological tissue in health and disease. Read more

Understanding the effects of immunomodulatory therapies on radiation response

Dying cancer cells are thought to be a rich source of tumour antigens and danger signals into the tumour microenvironment. Work from the Olcina lab has found that targeting complement can increase tumour cell death following radiotherapy which may in turn modulate anti-tumour immune responses. Read more

Nucleases and helicases as potential cancer targets

It is clear that the acquired genetic changes (vulnerabilities) in tumours can be exploited to treat cancer, increasingly in a manner tailored to individual patients. Read more

Investigating the role of E3 ubiquitin ligases in cancer pathogenesis

The Ubiquitin Proteasome System (UPS) is a crucial regulator of cell survival in normal conditions and after DNA damage. The function of UPS is dysregulated in cancer, thus providing a large repertoire of targets to exploit for better cancer treatment. Read more

Parallels between the biological response to viral infection and hypoxia

Regions of low oxygen or hypoxia occur in most solid tumours and predict for a poor patient outcome. Cancer cells adapt to hypoxic conditions and become resistant to therapy, therefore finding new strategies to target tumour hypoxia is essential to improve patient care. Read more

Characterisation of DNA-protein crosslink proteolysis repair in response to chemotherapy

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 or Topoisomerase inhibitors) and ionising radiation. Read more

Personalised Radionuclide Theranostics for Cancer

The adoption of highly effective anticancer radiopharmaceuticals such as 223Ra, 177Lu[Lu]-PSMA and 177Lu[Lu]-DOTATAE and, in some cases, their companion imaging tracers, into oncologic practise over the last few years has invigorated the field of radiopharmaceutical therapeutics. Read more

Functional analysis of a mutation in the SCN1A gene associated with Dravet syndrome

Sodium current through Nav1.1 channels plays an important role in neuronal depolarization. Mutations in the SCN1A gene encoding the structure of the α-subunit of Nav1.1 channels are the most common cause of monogenic epilepsy, which can manifest itself in its most severe form as the so-called Dravet syndrome. Read more

Neuronal excitability and its changes caused by a pathology

Adequate excitability is a basic parameter determining the physiological level of nerve tissue activity. Increased and decreased neuronal excitability can thus have a significant impact on the function of nervous tissue and is the basis of a number of neuropsychiatric diseases. Read more

3-year funded PhD studentship in cognitive neuroscience

Applications are invited for a 3-year funded PhD studentship in cognitive neuroscience, based across the Department of Psychological Sciences, Birkbeck, University of London (. Read more

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