The increase in bacterial infections which are resistant to all clinically approved antibiotics means that new treatments must be developed to overcome these resistance mechanisms. Read more
The gut barrier functions to prevent the passage of bacteria and bacterial products into the systemic blood circulation. If the gut barrier fails, bacterial products can infiltrate bodily tissues, causing metabolic and immune dysfunction. Read more
How cells respond to DNA replication stresses (e.g., DNA replication collapse, stalling or hyper-activity) is critical for their survival, and is a hallmark of cancers. Read more
Although cancers are highly mutated, it is factors above and beyond those mutations that allow a tumor to form. These factors include epigenetic gene programs embedded within the cell of origin (Baggiolini, et al, Science 2021). Read more
Project Description. How an individual responds to a vaccine can depend on what time of day that individual was vaccinated. This is evident across a number of vaccines for infectious disease including the COVID-19 vaccines. Read more
About the Project. The nuclear fuel cycle has generated higher-level radioactive wastes that will be disposed of in a deep geological facility (GDF) that will provide multiple barriers to the migration of radionuclides to the surface over prolonged timescales (tens of thousands of years). Read more
The Project. Multispecies microbial communities can outperform single species in, for example, producing pharmaceuticals or fighting infections. Read more
Using multi-species swards to reduce methane emissions in ruminants. The global agri-food sector will have to face the challenge of satisfying the food demand of 3 billion more people by 2050 in a sustainable, healthy, and equitable way. Read more
Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events 1. Read more
The International Centre for Brewing and Distilling (ICBD) at Heriot-Watt University in association with the Scotch Whisky Research Institute (SWRI) are offering an IBioIC-Industry co-funded PhD project, expected to commence by 30th September 2022. Read more
Applicants are invited to apply for a fully funded PhD programme to investigate the creation of biodegradable fibres from bacteria-generated bioplastics, i.e. polyhydroxyalkanoates (PHAs), with appealing mechanical competence and functionalities. Read more
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