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Microbiology PhD Research Projects

We have 415 Microbiology PhD Research Projects

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We have 415 Microbiology PhD Research Projects

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Exploring the Molecular Mechanism of Novel Mitochondrial Neurotoxins identified through a Machine Learning Approach

Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events (Will & Dykens, 2014). Read more

Deciphering host microbe interactions in inflammatory bowel disease

CLINICAL OPTION. Inflammatory bowel diseases (IBD) are chronic and debilitating conditions affecting over 5M people worldwide. They arise due a breakdown in the dialogue between the immune system and the intestinal microbiome, leading to aberrant inflammation. Read more

Redefining the metabolism of nitrogen cycling microbes using Dual Stable Isotope Probing (LEHTOVIRTA_UBIO22ARIES)

Primary Supervisor - Dr Laura Lehtovitra-Morley. Secondary Supervisor - Professor Matt Hutchings (John Innes Centre). Supervisory Team - Professor Colin Murrell (University of East Anglia, School of Environmental Sciences). Read more

Understanding complement system dysregulation in the tumour microenvironment

Inducing a stress response analogous to anti-viral immunity is important for maximising immune responses against the tumour. However, tumours evolve evasion strategies that can limit these responses. Read more

Understanding the effects of immunomodulatory therapies on radiation response

Radiotherapy can ablate tumours through inducing both DNA damage and anti-tumour inflammatory responses. However, innate immunity pathways mounting inflammatory responses can also afford cell intrinsic radioresistance. Read more

The crosstalk between tumour microenvironments and MAFF to determine transcriptional activation or repression

Radiation is effective in treating many types of cancers by inducing oxidative stress through the generation of reactive oxygen species (ROS) that result in DNA damage, in particular, DNA double strand breaks (DSBs). Read more

Ubiquitin signalling in the pathogenesis and radiotherapy of glioblastoma

Glioblastoma accounts for more than 4000 deaths every year in the UK. The cornerstone of glioblastoma treatment is constituted by maximal surgical resection, radiotherapy and chemotherapy. Read more

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