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University of Birmingham Molecular Biology PhD Projects

We have 17 University of Birmingham Molecular Biology PhD Projects

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Showing 1 to 15 of 17
  Regulation of host cell DNA damage response pathways by adenovirus
  Dr A S Turnell, Dr C McCabe
Applications accepted all year round

Funding Type

PhD Type

Human adenoviruses are small non-enveloped viruses with a linear, double-stranded DNA genome. Adenovirus has long served as a faithful model for dissecting the molecular basis of key cellular signalling pathways that regulate fundamental biological processes such as cell growth, cell differentiation and cell death.
  Analysing immune responses to metastatic ovarian tumours to identify therapeutic targets
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Creating “super” regulatory T cells to combat rejection, GVHD and autoimmunity through retroviral gene manipulation
  Dr N Jones, Dr S Lee
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Foxp3+CD25+CD4+ regulatory T cells (Treg) have been shown to be essential for the induction of tolerance to foreign organ transplants in experimental models.
  Investigating how ovarian tumours avoid immune responses in cancer patients
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Establishing a rationale for FGF23 modulation as a therapy in the critically ill patient
  Dr D Parekh, Prof D Thickett, Dr A Scott
Application Deadline: 1 September 2020

Funding Type

PhD Type

Research interests/description of main research theme. Everyone suffers at least one critical illness during their life. In the UK, 160,000 critically ill patients are admitted annually to intensive care units (ICU).
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  Understanding and combatting antimicrobial resistance plasmids
  Dr M Buckner, Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is a major crisis for human medicine. Globally, untreatable bacterial infections are rapidly increasing, leaving us with limited treatment options.
  Build and destroy: investigating targeted protein degradation in plant development and stress-response
  Dr D Gibbs
Applications accepted all year round

Funding Type

PhD Type

In order to effectively co-ordinate their growth and development, plants need to be able to respond to changes in their environment, whether it is adapting to the seasons or coping with stresses.
  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  Discovering molecular genetic mechanisms of central nervous system regeneration
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

Is it possible to promote regeneration of the central nervous system after injury, damage or disease? During normal development, neutrons and glia interact to coordinate the generations of neutrons and glia, and direct cell migration patterns, axonal navigation, dendritic arborisation and the emergence of neural circuits.
  Genetic analysis of the bacterial translocation machinery
  Dr D Huber
Applications accepted all year round

Funding Type

PhD Type

Every subcellular compartment in a cell contains proteins, and yet all of these proteins are initially synthesised in the same compartment.
  How does heterosis affect yield, quality and disease resistance in hybrid wheat?
  Dr P Borrill, Dr M Catoni, Dr C Uauy, Dr N Bird
Application Deadline: 7 June 2020

Funding Type

PhD Type

Heterosis, or hybrid vigour, is the increased performance of a hybrid relative to the parents. The use of hybrid cultivars in maize and rice have increased the performance of these crops substantially, but the same approach has not yet been widely exploited in wheat breeding.
  Molecular and genetic mechanisms of brain structural plasticity and neurodegeneration in the fruit-fly Drosophila.
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The brain changes throughout life. brain plasticity enables the brain to adjust in response to experience, whereas during aging natural neurodegeneration takes over.
  Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage.
  Understanding signalling networks underpinning key developmental processes during plant evolution
  Research Group: BBSRC MIBTP
  Dr J C Coates
Applications accepted all year round

Funding Type

PhD Type

Plants first appeared on land almost half a billion years ago. All land plants likely evolved from a single aquatic green algal ancestor.
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