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We have 20 Biochemistry PhD Research Projects for Self-funded Students in Nottingham

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Biochemistry PhD Research Projects for Self-funded Students in Nottingham

We have 20 Biochemistry PhD Research Projects for Self-funded Students in Nottingham

Nottingham Trent University

Nottingham Trent University is a research centre of excellence

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University of Nottingham

Research that changes lives and shapes the future

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Native mass spectrometry for the discovery of new anticancer agents

University of Nottingham School of Chemistry
BBSRC Doctoral Training Partnership, Researcher Academy. A 4-year fully funded BBSRC PhD CASE studentship is available at the University of Nottingham in collaboration with Erebagen Ltd to screen engineered bacterial natural product libraries for anti-cancer activity using native mass spectrometry. Read more
 Supervisor: Dr N Oldham
 3 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Exosome biogenesis and organelle trafficking in neurodegeneration.

University of Nottingham School of Life Sciences
Scientific summary. Intracellular transport pathways are fundamental for cell structure and function. Due to their longevity, complex morphology (long axonal and dendritic extensions) and requirement to maintain synaptic transmission, neurons are heavily dependent upon intracellular transport. Read more
 Supervisors: Dr A Hume, Dr DS Scott, Dr F Dajas-Bailador
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Overcoming replication stress–defining new mechanism from archaea to human

University of Nottingham School of Life Sciences
How cells respond to DNA replication stresses (e.g., DNA replication collapse, stalling or hyper-activity) is critical for their survival, and is a hallmark of cancers. Read more
 Supervisors: Dr E Bolt, Prof T Allers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Elucidating the role of lipids in fibrotic capsule formation at the surface of implanted medical devices.

University of Nottingham School of Medicine
Implanted medical devices are crucial in healthcare, valued at around £400 billion globally, however there is a high failure rate, often due to the foreign body reaction, where a fibrotic capsule forms around the implant with associated inflammation, loosening and infection. Read more
 Supervisors: Prof M Alexander, Prof AG Ghaemmaghami, Dr D H Kim, Prof BO Ollivere
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Functional characterization of gonococcal toxin-antitoxin systems

University of Nottingham School of Life Sciences
Toxin-antitoxin (TA) systems are commonly found in bacteria and comprise a stable toxin able to stall bacterial replication and an antitoxin that neutralises the activity of the toxin. Read more
 Supervisors: Dr N Oldfield, Dr D Turner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

Nottingham Trent University School of Science & Technology
The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more
 Supervisor: Dr A Antonysunil
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The Importance of Muscle Stem Cells: Implications for Muscle Repair in Inflammation and Trauma

University of Nottingham School of Medicine
Skeletal muscle possesses a remarkable capacity for adaptation and repair, processes essential in the maintenance of skeletal muscle health. Read more
 Supervisors: Dr S Joanisse, Prof P Greenhaff, Dr JM Mallinson, Dr C Deane
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Pectin supplementation to reduce gut and systemic inflammation and improve liver, muscle and gastrointestinal outcomes

University of Nottingham School of Medicine
A quarter of the world's population has metabolic dysfunction-associated steatotic liver disease, (which used to be known as non-alcoholic fatty liver disease). Read more
 Supervisors: Prof G Aithal, Dr J Grove, Dr KR Rollins, Prof AMV Valdes
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Structure and function of enzyme complexes involved in post-transcriptional gene regulation

University of Nottingham School of Pharmacy
Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

University of Nottingham School of Pharmacy
Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

University of Nottingham School of Pharmacy
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using genome engineering and bioinformatics to understand heterochromatin and centromere function in Schizosaccharomyces pombe and in cancer cells

University of Nottingham School of Life Sciences
Centromeres are the DNA sequences on eukaryotic chromosomes that mediate accurate chromosome segregation at both mitotic and meiotic cell divisions. Read more
 Supervisors: Dr W R A Brown, Dr W Wickstead
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of calcium signalling in regulating of tumour cell behaviour

University of Nottingham School of Life Sciences
Metastasis is the major cause of mortality in human cancers, yet we know relatively little of the fundamental biology that underlies the important transition to invasive malignancy. Read more
 Supervisors: Dr M Georgiou, Dr IM Maiellaro
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The use of Drosophila melanogaster to identify novel therapeutic agents for Alzheimer’s disease

University of Nottingham School of Life Sciences
Since 2003, our understanding of the causes of Alzheimer’s disease (AD) have improved considerably, however, in that time only one new drug treatment has been approved. Read more
 Supervisors: Dr M Georgiou, Dr Z Zhu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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How to build and maintain a 3-dimensional polarised epithelial sheet

University of Nottingham School of Life Sciences
We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more
 Supervisor: Dr M Georgiou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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