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Ophthalmology PhD Research Projects
We have 16 Ophthalmology PhD Research Projects
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Characterisation and treatment of patient iPSC-derived retinal organoids as an in vitro model of inherited retinal disease
Commercial partner: . Newcells Biotech Ltd. , Newcastle upon Tyne. Induced pluripotent stem cell (iPSC) derived 3D retinal organoids (ROs) mimic the architecture of the mammalian retina and can therefore be used as a physiologically relevant in vitro model. Read more
Identifying genetic mechanisms of neuronal regeneration using planaria
Neuronal injury or disease in humans often leads to disability and mortality. Neurons in humans regenerate poorly, and there are very few methods to encourage this regeneration. Read more
Exploring novel experimental therapeutics for mitochondrial disorders of the eye
Background. Primary mitochondrial genetic disease manifestations can involve almost all aspects of the eye. Mitochondrial disorders of the eye are often devastating genetic diseases, causing significant childhood and young adult blindness in the developed world. Read more
Three-dimensional structural mapping of the retinal neurovascular unit and the influence of diabetes
The aim of this PhD project is to better understand why people with diabetes are at risk of losing their vision. Diabetic retinopathy is a leading cause of visual impairment and blindness in developed countries. Read more
Diabetic Eye Disease: Minimising Impact, Maximising Reach
Diabetic eye disease related visual loss is still increasing. Read more
Investigating the ability of circadian clocks to mitigate degeneration of the back of the eye
Circadian clocks are present in most tissues and cells throughout the body, and have a crucial role in health and disease. Removal of clock factors can cause dysfunction. Read more
Bioengineering a full thickness cornea
Corneal blindness is the 4th leading cause of global blindness (WHO). Corneal scarring can be caused by trauma or infection and corneal replacement with donor corneas or synthetic (plastic) alternatives is currently the sole treatment to restore vision. Read more
Investigating a novel treatment for retinal scaring
Proliferative vitreoretinopathy (PVR) is a common pathological process following the detachment of the retina and is reported to develop in 5–10% of cases. Read more
Methods of modulation of mitochondrial function in glaucoma
Background. Glaucoma is a common, irreversible, optic neuropathy affecting the vision of predominantly older adults that slowly progresses over a period of years. Read more
Application of animal corneal cells for skin regeneration, tissue engineering and wound healing enhancement
Research Group:
Centre for Skin Sciences
Engineering of biological skin substitutes has progressed over the years from individual applications of skin cells, or biopolymer scaffolds, to combinations of cells and scaffolds for treatment, healing, and closure of acute and chronic skin wounds. Read more
Enhanced variant interpretation for the discovery of mechanisms underpinning Ophthalmic genomic disorders
This project will utilize large genomic sequencing datasets from the 100,000 genomes project and the UK BioBank to understand how genomic variation impacts the development and function of cells vital for correct vision. Read more
PhD position offered within EU Marie Sklodowska-Curie Initial Training Network EYE: European Young Eye
Short description of project. EYE is a project funded under H2020-ITN-2020 call (industrial doctorate modality). EYE will provide training and professional development in Vision Sciences and Optical Imaging Technologies to 5 Early Stage Researchers (ESR). Read more
Mechanisms underlying the effects of light and visual stimuli on mood
Light is not only important for vision, light responsiveness extends to fundamental aspects of mood, cognition, and performance. Read more
The circadian clock as a regulator of information processing
Endogenous biological clocks are a ubiquitous feature of living organisms, driving rhythms in countless cellular and physiological functions, and influencing almost all biological processes. Read more
Designing an Internet-based intervention for carers and adults with acquired visual loss
Research Group:
Vision and Hearing Sciences Research Group
Research Group. Vision and Hearing Sciences Research Group. Proposed supervisory team. Prof Peter Allen. Dr Eldre Beukes. Prof Gerhard Andersson (External). Read more
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