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Pathology (self) PhD Research Projects

We have 27 Pathology (self) PhD Research Projects

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We have 27 Pathology (self) PhD Research Projects

The role of UV exposure and novel compounds on the immunogenicity and genotoxicity of skin cancer

  Research Group: Chemistry and Biosciences
The major aims of this project are to investigate the effect of UV in the development of different skin cancers compared to spontaneously regressing precancerous lesion, keratoacanthoma; and the effect of a novel compounds such as the structurally modified retinoic acid in the treatment of skin cancers and other cutaneous lesions. Read more

Investigating the pathogenesis of human papillomavirus (HPV) in anal cancers

Infection with human papillomavirus (HPV) is associated with ~5% of all human cancers, in particular cervical cancer. Whilst less common, HPV is also associated with the vast majority (~93%) of anal cancers in the UK. Read more

Investigating the role of the regulatory renin-angiotensin system in protecting against synaptic dysfunction in Alzheimer’s disease

Rationale. Mid-life hypertension is a modifiable risk factor for Alzheimer’s disease (AD) and blood pressure lowering drugs, especially those that target the brain renin-angiotensin system (RAS), lowers the incidence of AD, and reduces the conversion of MCI and slows the progression of AD. Read more

Molecular dissection of cell-extracellular matrix interactions in hepatic homeostasis and the development of fibrosis

The overall long-term goal is to increase our currently limited understanding of mechanisms by which extracellular matrix (ECM) contributes to liver homeostasis and the development and progression of liver fibrosis. Read more

Clinical: Gastroesophageal reflux in respiratory disease: pathogenic role and improved management

Gastroesophageal reflux disease (GERD) is a condition in which stomach contents, such as food and acid pass into the gullet/oesophagus causing heartburn. GERD is very common in patients with lung disease, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Read more

Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Selective drug uptake by cell surface transporters

Cell surface transporters and not diffusion is responsible for the transfer of metabolites across a cell’s membrane. Many types of drugs are structurally very similar to natural metabolites and as a consequence they are treated by the cell as though they are the natural homologue. Read more

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