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Pathology PhD Projects

We have 85 Pathology PhD Projects

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  PhD position/Graduate Research Assistantship in the area of Allergy, Asthma and Immunology
  Dr A Mishra
Application Deadline: 14 March 2020

Funding Type

PhD Type

The Laboratory of Lung Inflammation, Department of Pathobiology, College of Veterinary Medicine at Auburn University have opening for highly motivated PhD candidate/ Graduate Research Assistant to work on NIH-funded research project in the area of Allergy, Asthma and Immunology.
  Budding yeast as a model for sudden cardiac death
  Dr T Hoefken
Applications accepted all year round

Funding Type

PhD Type

Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm.
  Understanding resistance and tolerance to chytrid fungal disease in amphibians to improve conservation
  Dr L Grogan, Dr DN Newell, Prof H McCallum
Application Deadline: 23 September 2019

Funding Type

PhD Type

This PhD project will involve working with captive animals (endangered Fleay’s barred frogs and tadpoles) to understand host responses to infection and mechanisms of resistance and tolerance to the devastating fungal disease, frog chytridiomycosis.
  Biomechanics of orthotic treatment for hand pathology
  Dr A Kedgley
Application Deadline: 1 October 2019

Funding Type

PhD Type

Applications are invited for a 4-year PhD studentship in the biomechanics of orthotic treatment for hand pathology, within the group headed by Dr Angela Kedgley (http://www.kedgley.org), to be carried out within the Department of Bioengineering at Imperial College London.
  Influence of HIV-1 opsonization on APC functions with regard to persistence of the virus and opportunistic pathogens, such as Mycobacteria spp. within relevant human 3D models
  Prof D Wilflingseder, Prof S Niemann
Application Deadline: 10 November 2019

Funding Type

PhD Type

HIV-1 and Mycobacterium tuberculosis represent detrimental co-epidemics worldwide, particularly in sub-Saharan Africa, and co-infection accelerates progression of both diseases.
  Curing Genetic Muscle diseases
  Dr J Ochala
Applications accepted all year round

Funding Type

PhD Type

Congenital myopathies are a group of genetic muscle diseases with unclear mechanisms and no efficient treatment.
  Understanding the cytoskeletal and biophysical changes associated with fibroblast activation during scar formation
  Dr B Stramer, Dr T Shaw
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Dr. Brian Stramer (https://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/motility/stramer/index) in the Randall Centre for Cell and Molecular Biophysics, King’s College London.
  Potential therapeutic effects of natural products in Human Papillomavirus (HPV) related cervical cancers
  Dr H Ashrafi
Applications accepted all year round

Funding Type

PhD Type

Cervical cancer is one of the most common types of cancer affecting women worldwide. Infection caused by high-risk human papillomaviruses (HPVs), especially type 16 and 18 are implicated in the etiology of most cervical cancers.
  The role of matrix interactions in regulating the SPARC family of matricellular proteins.
  Dr N Hill, Dr A Munasinghe
Applications accepted all year round

Funding Type

PhD Type

The SPARC family of matricellular proteins determine the way in which cells respond to their extracellular environment. SPARC family proteins interact with a range of binding partners, including matrix proteins (1).
  Identification of novel complement evasion mechanisms developed by bacterial pathogens
  Prof A Blom, Prof S Rooijakkers
Application Deadline: 10 November 2019

Funding Type

PhD Type

The project is focused on discovery of new complement evasion mechanisms developed by bacterial pathogens. One of the studied bacteria will be opportunistic Filifactor alocis, a recently identified periodontal pathogen of major importance but still poorly studied.
  The role of oesophageal submucosal glands in epithelial homeostasis and the development of Barrett’s oesophagus
  Research Group: Cancer Biology & Surgical Oncology Laboratory
  Prof W. Phillips, Dr N. Clemons
Applications accepted all year round

Funding Type

PhD Type

Barrett’s oesophagus, the premalignant precursor of oesophageal adenocarcinoma, is a metaplastic condition where the normal stratified squamous epithelium that lines the oesophagus is replaced by an intestinal-like columnar epithelium.
  Genomic determinants of long-term survival in ovarian cancer
  Research Group: Cancer Genetics & Genomics Laboratory
  Prof D. Bowtell, Dr D Garsed
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer is an aggressive disease in which only ~30% of women survive 5 years or more. Despite a poor prognosis, a subset of patients are highly responsive to chemotherapy, and some become long-term survivors (>10 years survival).
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Computational simulation of tumour formation and progression
  Dr D. Goode
Applications accepted all year round

Funding Type

PhD Type

Tumours comprise a complex mix of related but distinct cellular subpopulations that both compete and complement one another. These dynamics strongly influence how and when a tumour forms as well as its response to therapy, however there are hard to observe directly.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Squamous cell carcinomas (SCC) are amongst the most common cancer types afflicting man. SCCs most frequently arise from stratified squamous epithelia such as the epidermis or the mucosae of the head and neck.
  Mechanisms of regulating gene expression via selective mRNA transport
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
  Overcoming therapy induced reprogramming of metabolism in melanoma
  Dr K. Sheppard, Dr L Smith
Applications accepted all year round

Funding Type

PhD Type

Therapies that target oncogenes in cancer have revolutionised cancer care. The major benefits of targeted therapies are high response rates and manageable toxicities, however they do not result in cures in the vast majority of patients.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Role of the tumour microenvironment in gastric cancer
  Dr A. Boussioutas, Dr R. Busuttil
Applications accepted all year round

Funding Type

PhD Type

Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients.
  Targeting IDH mutations in acute myeloid leukaemia
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is an aggressive disease with poor prognosis and development of novel treatment options is urgently needed.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
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