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Pathology PhD Research Projects

We have 32 Pathology PhD Research Projects

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I am a European student


We have 32 Pathology PhD Research Projects

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Managing polymicrobial biofilm formation on tracheostomy tubing

Tracheostomy tubes are used widely to aid vulnerable patients with impaired airway function. They can be applied across a range of scenarios, from intensive care units to home care settings, and can remain within the patient for periods ranging from one week to many years. Read more

Go with the flow: the why and how of cardiovascular disease

Have you ever wondered why and how cardiovascular disease and atherosclerotic plaques develop in the areas that they do? Why is it that some arteries are prone to blockage while others are protected? The answer lies with blood flow. Read more

Epigenetic regulation of cholangiocarcinoma growth

Cholangiocarcinoma (CCA) is a rare malignant bile duct tumour with an average incidence of 1/100,000 in the population per year. The overall incidence of CAA includes 15% of primary liver cancers, the second most common type of primary liver cancer. Read more

Therapeutic targeting of chemokines in inflammation

Protein interactions underlie most biological processes but are challenging to target using small molecule drugs. Many protein interactions are mediated by short-linear-interacting motifs (SLiMs) that range from 3-12 amino acid residues (1, 2). Read more

Investigating the mechanism maintaining centromere integrity

The centromere is a region of chromatin that serves as a platform for the kinetochore machinery assembly, hence is essential for accurate chromosome segregation during cell division. Read more

Developmental origins of high-risk childhood leukaemia

Leukaemia is the commonest childhood cancer and occurs when blood formation (haematopoiesis) is perturbed because of a genetic/molecular abnormality in haematopoietic stem and progenitor cells (HSPC). Read more

De Novo Mutations and Human Disease

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most originate, the human testis. Read more

De Novo Mutations and Human Disease

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most originate, the human testis. Read more

Organelle dynamics in health and disease

The inside of a cell is crowded with many different organelles. For example, cells typically contain hundreds of mitochondria that produce energy, and hundreds of peroxisomes that make important chemicals. Read more

RNA biology in neurons

Multiple neuronal processes, including axon guidance, learning and memory, rely on asymmetric localisation and translation of mRNAs within a neuron. Read more

Viral manipulation of host cell biology for assembly, secretion and immune evasion.

This project will investigate mechanisms of assembly, secretion and immune subversion adopted by (+)RNA viruses, with a particular emphasis on Dengue/Zika from the flavivirus and SARS-CoV-2 from the coronavirus families. Read more

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