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Pathology PhD Research Projects

We have 60 Pathology PhD Research Projects

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We have 60 Pathology PhD Research Projects

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EASTBIO The Role of Protein Methylation in the Differentiation and Function of Motor Neurones

  Research Group: Biomedical Sciences Research Centre
BACKGROUND. The methylation of proteins is a key post-translational modification used for fine-tuning vital cellular processes. In recent years, it has become apparent that proper regulation of protein methylation is vital for the correct formation of sub-cellular structures, including nuclear Cajal bodies and gems. Read more

Tripartite synapses – a weak link in Motor Neuron Disease?

Neurons transmit information via trillions of synapses found throughout the nervous system. Some synapses receive contacts from non-neuronal cells, called astrocytes, which ‘listen in’ on neuronal communication and signal back to modulate neural activity. Read more

MRC DiMeN Doctoral Training Partnership: Nanoscale structural mapping of protein aggregates in human disease

Type-2 diabetes (T2D) is a chronic metabolic disorder, characterised by high blood glucose, variable resistance to insulin, and at least a relative deficiency in insulin levels caused by loss of β-cell function within pancreatic islets. Read more

Modelling cell connectivity in bone and its consequences for healthy ageing and regeneration.

Background. Maintenance of bone integrity is a key challenge for the ageing population and for regenerative biology. Bone is actively produced, remodelled and repaired throughout life and disruption of this process causes fragility, disability and failed regeneration. Read more

Viral manipulation of host cell biology for assembly, secretion and immune evasion

This project will investigate mechanisms of assembly, secretion and immune subversion adopted by (+)RNA viruses, with a particular emphasis on Dengue/Zika from the flavivirus and SARS-CoV-2 from the coronavirus families. Read more

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