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Pharmacology / Toxicology PhD Research Projects

We have 195 Pharmacology / Toxicology PhD Research Projects

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We have 195 Pharmacology / Toxicology PhD Research Projects

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Helminth products as macrophage “trainers”: a novel therapeutic tool for the treatment of immune mediated diseases

The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more

Development of novel herbal extracts for treatment of metabolic disarray and neuropathy in rodent models of obesity and diabetes.

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference No. SHLS20041. Diabetes and obesity levels continue to rise globally, with significant detrimental effects on personal health and wellbeing, social welfare and healthcare budgets. Read more

Characterisation of novel inhibitors of vascular injury due to inflammation

Myeloperoxidase (MPO) is a haemoprotein that is highly expressed in neutrophils and is secreted during injury and inflammation to assist in host defence reactions by producing antimicrobial reactive oxygen species. Read more

Novel strategies for the diagnosis and treatment of snakebites

Snakebite envenomation (SBE), a high priority neglected tropical disease affects several million people worldwide resulting in as many as 150,000 deaths and around 500,000 permanent disabilities every year. Read more

Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular/inflammatory diseases

"Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke. Read more

Ion channel regulation in models of neurodegeneration

Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated. Read more

Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more

Macromolecules for drug delivery

We have worked with a number of water soluble polymer systems that are capable of encapsulating and solubilising various hydrophobic drug moieties. Read more

Artificial blood

Inspired by Nature, we have developed a number of macromolecules that can bind a release oxygen. These have included polyfluorinated micelles, polyion complexes and porphyrin cored polymers. Read more

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