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Pharmacology / Toxicology PhD Research Projects

We have 188 Pharmacology / Toxicology PhD Research Projects

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We have 188 Pharmacology / Toxicology PhD Research Projects

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Polo-like kinase inhibitors for targeted treatment of adrenocortical carcinoma

Dr Ronchi is a clinician scientist and an Endocrinologist with long-standing expertise in endocrine tumors. Her research field mostly focuses on molecular markers involved in the pathogenesis and prognosis of adrenocortical carcinoma (ACC), a rare orphan disease with several unmet needs. Read more

Using CRISPR in iPS cells to modify platelet function

Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus. Read more

Brk and mTOR signalling: implications for Taxol resistance

One of the major causes of death amongst breast cancer patients is due to the development of distal metastases and the acquisition of resistance to chemotherapeutic agents. Read more

Investigating microvascular dysfunction in sickle cell disease (SCD)

Cerebrovascular disease is a leading cause of mortality worldwide, with numbers on the rise. It is a serious complication of a number of disease states, including sickle cell disease (SCD), an inherited autosomal recessive disorder, resulting from a single amino acid substitution in the haemoglobin β chain. Read more

Pharmacological strategies to promote resolution of inflammation in disease

Inflammation plays a crucial role in the pathophysiological cascade of ischaemia reperfusion injury (I/RI), the incidence of which is extensive including myocardial infarction, stroke, peripheral artery disease, solid organ transplantation, sepsis, inflammatory bowel diseases, blood disorders (e.g. Read more

Marine Mammal Ecotoxicology

Exposure to persistent organic pollutants such has been shown to cause reproductive failure in wild seals and other aquatic mammal species and endocrine disruptive toxic mechanisms are believed to be involved. Read more

Towards the development of a novel class of broad-spectrum anti-infective drugs

Through exceptionally strong research collaborations at the interface of chemistry, biology, and medicine, we have applied innovative thinking to the field of (Minor Groove Binders) MGBs to develop a novel platform for drug discovery with the potential to treat an impressive range of diseases, including bacterial, fungal, parasitic, and viral infections. Read more

Targeting Connexin and Pannexin channel signalling in Diabetic Retinopathy

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference. SHLS20042. Diabetic retinopathy (DR) is a microvascular consequence of diabetes mellitus (both Type 1 and Type 2) affecting more than a third of diabetics (affecting an estimated 100million people worldwide). Read more

Pharmaceutical cocrystallisation for improved medicines

  Research Group: Centre for Pharmaceutical Engineering Science
Active pharmaceutical ingredients (APIs) are frequently delivered to the patients in the solid-state formulation. Numerous tons of tablets are produced daily worldwide by pharmaceutical industry. Read more

SELF-FUNDING MSc BY RESEARCH PROJECT: Cystic fibrosis: restoring ion transport with small molecules

Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a unique ATP-binding cassette transporter that functions as an ATP-gated anion channel, playing a pivotal role in salt and water movement across epithelial tissues (1). Read more

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