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University of Reading Pharmacology / Toxicology PhD Projects

We have 12 University of Reading Pharmacology / Toxicology PhD Projects

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Showing 1 to 10 of 12
  Maximising the efficacy of polyphenols on cardiovacular health
  Dr C Mills
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular diseases are the worlds’ leading cause of death. Dietary approaches to prevent or treat these diseases are becoming increasingly accepted.
  Studying the mechanisms that cause heart failure
  Dr S Boateng
Applications accepted all year round

Funding Type

PhD Type

Heart failure has a serious impact on our society and once diagnosed has a poor survival rate. In the United Kingdom, there are about 1.5 million people living with the after-effects of a heart attack, and this presents a huge economic burden each year.
  The molecular mechanisms of thrombosis and haemostasis
  Dr C.E. Hughes
Applications accepted all year round

Funding Type

PhD Type

A healthy cardiovascular system relies on the cells lining the blood vessels (endothelial cells) and heart cells (cardiomyocytes) to function normally.
  The molecular mechanisms underpinning individual variation in platelet function and their effect on the progression and treatment of cardiovascular disease.
  Dr CI Jones
Applications accepted all year round

Funding Type

PhD Type

Platelets are small blood cells that play a vital role in the chronic and acute progression of Cardiovascular Disease (CVD). Platelets respond to a range of agonists, which are released when blood vessels are damaged, by aggregating together to form thrombi.
  Using CRISPR in iPS cells to modify platelet function
  Dr C.E. Hughes
Applications accepted all year round

Funding Type

PhD Type

"Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus.
  Functional Selectivity and the Regulation of Receptor-Activated Signaling Pathways
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round

Funding Type

PhD Type

The molecular mechanisms that regulate receptors and receptor-activated signaling pathways in the cardiovascular and nervous systems are complex.
  Ion channel regulation in models of neurodegeneration
  Dr M Dallas, Prof G J Stephens, Dr A Bithell
Applications accepted all year round

Funding Type

PhD Type

Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated.
  Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
  Dr D Widera
Applications accepted all year round

Funding Type

PhD Type

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells.
  Novel strategies for the diagnosis and treatment of snakebites
  Dr S Vaiyapuri
Applications accepted all year round

Funding Type

PhD Type

Snakebites represent a major neglected tropical disease affecting several million people worldwide and resulting in as many as 150000 deaths each year.
  The effect of omega-3 polyunsaturated fatty acids (n-3 PUFA, “fish oils”), on vascular and potassium channel function
  Dr A McNeish, Dr G Cottrell, Dr F Tamagnini
Applications accepted all year round

Funding Type

PhD Type

There is a large body of evidence that consumption of oily fish or supplementation of fish oils leads to improvements in cardiovascular heath (as well as other health benefits including anti-inflammatory and anti-cancer effects).
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