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Structural Biology PhD Research Projects

We have 86 Structural Biology PhD Research Projects

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We have 86 Structural Biology PhD Research Projects

Insights into eye disease: understanding the molecular basis of age-related macular degeneration

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more

Evolution of vertebrate blood vessels

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more

Application of cryo-EM to understanding of GPCR structure, function and drug discovery - Drug Discovery Biology, Monash University (Australia)

GPCRs are among the most important therapeutic drug target classes. The existing technical advances in GPCR cryo-EM provide a robust template for the generation of novel structures that could be used to facilitate new drug design and development. Read more

How do evolutionary changes in innate immune genes influence the carriage of zoonotic pathogens

Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. How diversity in host immune genes across species impact upon pathogen carriage are poorly understood. Read more

Mechanisms of induction of protective lung tissue resident memory cells against influenza

Influenza is a global health threat to humans and livestock and animal influenza viruses are the CDC’s top zoonotic pathogen. There is a critical need to develop vaccines that provide broad protection and decrease the need for annual immunisation. Read more

The chemistry and biophysics of phosphoryl transfer enzymes

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates. Read more

Molecular mechanisms underlying Parkinson's disease

There is great need for improved understanding of the mechanistic biology underlying Parkinson’s disease. Such knowledge will help with development of new drugs that slow or even halt the progression of the disease. Read more

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