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Structural Biology PhD Research Projects

We have 167 Structural Biology PhD Research Projects

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We have 167 Structural Biology PhD Research Projects

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EASTBIO Biocatalyst cascades for drug synthesis

Project Details. Natural and engineered biocatalysts are already having impact in the manufacture of high value pharmaceuticals by catalysing the conversion of functional groups in high yield. Read more

Trapping BAM in action: A target for the development of new antibacterial strategies

Antibiotic resistance by gram-negative bacteria is a significant challenge, with pathogens of this class comprising 9 of the 12 bacteria that pose the greatest threat to human health, as identified by the World Health Organisation. Read more

Navigating through sequence space to understand Alpha-Synuclein Aggretion

The aggregation of the 140 residue protein a-synuclein into amyloid fibres is associated with neurodegenerative diseases known as synucleinopathies including Parkinson’s disease (the second most common neurodegenerative disease worldwide). Read more

Deciphering the in vivo RNA structure code in regulating protein translation in plants (DING_J22DTP2)

Codon optimisation is a common method in synthetic biology to achieve high levels of protein expression. It relies on the creation of so-called “silent” or synonymous mutations within a coding sequence, such that the DNA/RNA sequence is altered but the resulting amino acid sequence remains unchanged. Read more

Location location location - how genome position affects gene expression (WEBBER_Q22DTP)

Bacterial genomes have evolved over billions of year to allow efficient expression of the right genes at the right times. It has become clear that the same gene, placed in different locations around a bacterial chromosome can display very different levels of expression. Read more

*Eastbio*: Serum albumin glycation and its impact on Zn2+-dependent haemostasis and insulin dynamics

Zinc is an essential micronutrient in mammals, vital to virtually all physiological pathways and processes. High nanomolar concentrations of free zinc ions (Zn2+) are cytotoxic; therefore, extracellular zinc is usually well-buffered. Read more

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