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Structural Biology PhD Research Projects

We have 167 Structural Biology PhD Research Projects

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We have 167 Structural Biology PhD Research Projects

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EASTBIO CASE Molecular engineering of the ubiquitin-proteasome system: A new approach to pathogen resistance in plants

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Barley (Hordeum vulgare) is the fourth most important crop worldwide and second in the UK. Diseases, including those caused by the brown rust pathogen, Puccinia hordei, cause barley yield losses of up to 40%. Read more

EASTBIO The role of host membrane protein interactions in herpesvirus nuclear egress and SARS-CoV-2 double membrane vesicle formation

  Research Group: Institute of Cell Biology
    Viruses have many critical interactions with host cell membranes that mostly take advantage of host cell proteins. The Schirmer and Graham labs have 2 lines of investigation involving virus interactions with host cell membrane proteins that could be individually or jointly carried further in this PhD project. . Read more

EASTBIO Bone biomineralisation

This project will investigate the fundamental mechanisms which regulate bone mineralisation through extracellular vesicles. A deeper understanding of this process will expose new therapeutic targets for the treatment of bone disorders. Read more

EASTBIO Expanding the chemistry of non-heme enzymes

Chemical synthesis is widely viewed as being unsustainable. Whilst this is an oversimplification, in many cases chemical production still relies on petrochemicals, rare metals and high energy consumption to make the products we need for modern life. Read more

EASTBIO New chemical tools to understand and exploit tubulin diversity

Microtubules are long polymers important for cell division, intracellular transport and polarity. Many isotypes of microtubules co-exist in human cells and levels of expression vary with the cell type. Read more

EASTBIO Molecular and regulatory insights into getting out of mitosis

  Research Group: Institute of Cell Biology
The fidelity of chromosome segregation is essential to ensure genome stability. Failure to exit mitosis and complete cell division results in tetraploidy and extra centrosomes which is a path to tumour development and drug resistance. Read more

EASTBIO An integrated approach to deciphering the role of proline in intrinsically disordered protein regions

Proteins often have a well-defined structure that is key to it performing their function. Intrinsically disordered regions (IDRs) have no defined 3D structure and are found in many proteins, yet their purpose is poorly understood. Read more

EASTBIO Seeing double: how do dsRNA binding pseudoenzymes regulate vertebrate mRNAs?

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Pre-mRNAs and mRNAs are regulated post-transcriptionally by a variety of different mechanisms that include splicing and editing, which alter the information content of the RNAs. Read more

EASTBIO Structure-function analysis of a plant virus RNA transport protein

  Research Group: Biomedical Sciences Research Centre
Background. Plant viruses are major crop pathogens which cause $60 billion annual damage to the global agri-economy and threaten sustainable food production. Read more

Molecular regulation of autophagy

Talented and motivated students passionate about doing research are invited to apply for this PhD position. The successful applicant will join the Crick PhD Programme in September 2022 and will register for their PhD at one of the Crick partner universities (Imperial College London, King’s College London or UCL). Read more

Development of novel biotechnologies for scientific and medical applications

Talented and motivated students passionate about doing research are invited to apply for this PhD position. The successful applicant will join the Crick PhD Programme in September 2022 and will register for their PhD at one of the Crick partner universities (Imperial College London, King’s College London or UCL). Read more

Cryomicroscopy of lipid-enveloped virus structure and entry mechanisms

Talented and motivated students passionate about doing research are invited to apply for this PhD position. The successful applicant will join the Crick PhD Programme in September 2022 and will register for their PhD at one of the Crick partner universities (Imperial College London, King’s College London or UCL). Read more

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