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Structural Biology PhD Research Projects

We have 156 Structural Biology PhD Research Projects

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We have 156 Structural Biology PhD Research Projects

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Modulating the ubiquitin ligase activity of MDM2

p53 tumour suppressor protein becomes activated in response to various genotoxic stresses and induces a variety signalling programmess to restore cellular homeostasis. Read more

Synthetic Biology Approaches to Sensing Pathogenic Viruses and Narcotics

Engineering biology and its place in sensing. One of the key attributes of life is the ability to respond to stimuli. Nature has evolved a wide array of molecules, tissues and organs that sense stimuli as diverse as light, taste, pressure, odour, pheromones and drugs. Read more

EASTBIO New chemical tools to understand and exploit tubulin diversity

Microtubules are long polymers important for cell division, intracellular transport and polarity. Many isotypes of microtubules co-exist in human cells and levels of expression vary with the cell type. Read more

EASTBIO Investigating the Assembly of Bacterial Encapsulins for the Efficient Engineering of Nanoscale Bioreactors

Encapsulins are bacterial capsid-like nanocompartments roughly 25-30 nm in diameter. These large protein assemblies are made up of either 60 or 180 copies of a single 30 kDa protomers which assemble to form a hollow icosahedral protein cage. Read more

EASTBIO Expanding the chemistry of non-heme enzymes

Chemical synthesis is widely viewed as being unsustainable. Whilst this is an oversimplification, in many cases chemical production still relies on petrochemicals, rare metals and high energy consumption to make the products we need for modern life. Read more

EASTBIO Bone biomineralisation

This project will investigate the fundamental mechanisms which regulate bone mineralisation through extracellular vesicles. A deeper understanding of this process will expose new therapeutic targets for the treatment of bone disorders. Read more

EASTBIO Biocatalyst cascades for drug synthesis

Project Details. Natural and engineered biocatalysts are already having impact in the manufacture of high value pharmaceuticals by catalysing the conversion of functional groups in high yield. Read more

EASTBIO An integrated approach to deciphering the role of proline in intrinsically disordered protein regions

Proteins often have a well-defined structure that is key to it performing their function. Intrinsically disordered regions (IDRs) have no defined 3D structure and are found in many proteins, yet their purpose is poorly understood. Read more

EASTBIO: Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signaling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

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