University of Leeds Structural Biology PhD Projects, Programmes & Scholarships

We have 20 University of Leeds Structural Biology PhD Projects, Programmes & Scholarships

Alpha-synuclein amyloid in Parkinson's disease: using Nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons

University of Leeds Faculty of Biological Sciences

Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more

Supervisors: Dr E W Hewitt, Prof S E Radford, Dr P Actis

Year round applications PhD Research Project Self-Funded PhD Students Only

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Control and inhibition of virus replication

University of Leeds Faculty of Biological Sciences

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

Supervisor: Dr A.K Tuplin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM

University of Leeds Faculty of Biological Sciences

The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Read more

Supervisors: Prof N A Ranson, Prof S E Radford

Year round applications PhD Research Project Self-Funded PhD Students Only

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Design and Folding of beta barrel membrane proteins

University of Leeds Faculty of Biological Sciences

The cell walls of Gram negative bacteria are packed with b-barrel outer membrane proteins (OMPs) whose function are essential for bacterial growth and virulence. Read more

Supervisors: Prof S E Radford, Prof D B Brockwell

Year round applications PhD Research Project Self-Funded PhD Students Only

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How does myosin 10 contribute to filopodia formation and stability?

University of Leeds Faculty of Biological Sciences

How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through the extracellular matrix, especially important in driving cancer cell metastasis. Read more

Supervisors: Prof M Peckham, Dr D Tomlinson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using cryo-electron microscopy to study large protein complexes that mediate the female post-mating response

University of Leeds Faculty of Biological Sciences

In many animals, male seminal fluid alters female physiology and post-mating behaviour to ensure paternity of the offspring. However, how seminal fluid components elicit these post-mating responses is poorly understood. Read more

Supervisors: Dr J.J.B. Cockburn, Prof R E Isaac

Year round applications PhD Research Project Self-Funded PhD Students Only

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Engineering Developable Biopharmaceuticals

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Prof D B Brockwell, Prof S E Radford

Year round applications PhD Research Project Self-Funded PhD Students Only

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Uncovering the viral and cellular components that dictate the neurological outcome of tick-borne encephalitis virus infection

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisor: Dr NG Goonawardane

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structural and mechanistic studies of fibroblast growth factor receptor signalling

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Prof A.L. Breeze, Prof F. Sobott

Year round applications PhD Research Project Self-Funded PhD Students Only

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Machine Learning and Molecular Modelling in Mass Spectrometry

University of Leeds Faculty of Biological Sciences

This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more

Supervisors: Prof F. Sobott, Dr A Kalli, Dr H Wang

Year round applications PhD Research Project Self-Funded PhD Students Only

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Seeing inside the brain of Alzheimer’s disease by cryoET

University of Leeds Faculty of Biological Sciences

The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more

Supervisor: Dr R Frank

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of ubiquitin-modifying enzymes in angiogenesis

University of Leeds Faculty of Biological Sciences

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Dr S Ponnambalam, Dr M A Harrison

Year round applications PhD Research Project Self-Funded PhD Students Only

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Untangling the role of beta-1,3 glucan polymers in intercellular communication

University of Leeds Faculty of Biological Sciences

Apply to join the Benitez-Alfonso team in their quest to dissect the mechanisms underpinning the function of beta-1,3 glucan polymers in plant growth and development. . Read more

Supervisor: Dr Y Benitez-Alfonso

Year round applications PhD Research Project Self-Funded PhD Students Only

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Uncovering the links between the environmental sensor, AHR, and the development of breast cancer

University of Leeds Faculty of Biological Sciences

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisors: Dr C Gorrini, Dr A Zhuravleva

Year round applications PhD Research Project Self-Funded PhD Students Only

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Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens

University of Leeds Faculty of Biological Sciences

Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more

Supervisor: Prof A O'Neill

Year round applications PhD Research Project Self-Funded PhD Students Only

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NIHR Leeds BRC: Pre-clinical evaluation of novel regenerative medicine strategies for knee osteoarthritis

University of Leeds Faculty of Medicine and Health

Historically, articular cartilage was considered incapable of spontaneous repair. However, biomechanical correction in osteoarthritis (OA) using high tibial osteotomy or joint distraction demonstrated the remarkable joint to regeneration by “merely” correcting joint alignment. Read more

Supervisors: Prof H Pandit, Prof D McGonagle

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

University of Leeds Faculty of Medicine and Health

Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more

Supervisors: Dr R Ariens, Prof D J Beech, Dr E Levelt

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

University of Leeds Faculty of Biological Sciences

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Supervisor: Dr J Boyes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Fully Funded 4-Year Cheney Scholarship PhD Programme in In Situ Structural Biology

University of Leeds

Exciting new developments in imaging and structural methods, known as “in situ structural biology”, can reveal the structure and behaviour of biological macromolecules inside healthy and diseased cells and tissues. Read more

Funded PhD Programme (Students Worldwide) 4 Year PhD Programme

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Virology: Unique Antiviral Therapy targeting Zika and Related Viruses

University of Leeds Faculty of Medicine and Health

Zika Virus (ZIKV) has emerged as a new mosquito-borne threat to public health after the devastating South American outbreak. Read more

Supervisors: Dr S Griffin, Dr A Kalli, Dr C McKimmie

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 20 University of Leeds Structural Biology PhD Projects, Programmes & Scholarships

University of Leeds Structural Biology PhD Projects, Programmes & Scholarships

We have 20 University of Leeds Structural Biology PhD Projects, Programmes & Scholarships

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