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Toxicology PhD Research Projects

We have 42 Toxicology PhD Research Projects

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We have 42 Toxicology PhD Research Projects

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Redefining the use of steroids in endometriosis: key mechanisms and new solutions

Endometriosis is a debilitating condition that affects an estimated 190 million women of reproductive-age worldwide [1]. In endometriosis, cells similar to the lining of the uterus typically form lesions around the bowel, ovaries and bladder, causing chronic inflammation and scarring. Read more

Systems Biology of Cellular Stress Response

Our cells are exposed to a large number of chemicals such as food additives, water contaminants and pollution in the air etc. Exposure to many of these leads to toxic effect and in some cases cancer and other diseases. Read more

Synthetic transition metal catalysts for the treatment of cancer

Working the interfaces of chemical catalysis, analytical chemistry, cellular biology, pharmacology and medicine, this project provides unique interdisciplinary training in the skills required for the development of a pre-clinical metal-based therapy. Read more

Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease

The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more

Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
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Interdisciplinary PhD in the field pharmaceutical science

Doctoral Programme Interdisciplinary PhD Programme in Medical and Health Sciences is offered in disciplines in which the Jagiellonian University has the authority to award a doctor’s degree. Read more

Formulation of heterogenous solid dispersions produced by spray drying and hot-melt extrusion for improved delivery of amorphous drugs

  Research Group: Pharmacology and Experimental Therapeutics
Production of the amorphous solid dispersions (ASDs) is a one of the methods of improving of physicochemical properties of an active pharmaceutical ingredient (API) such as its solubility and physicochemical stability. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

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