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University of Birmingham PhD Projects

We have 115 University of Birmingham PhD Projects

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Showing 31 to 45 of 115
  Evolution of multi-drug resistant gram negative clones
  Dr A McNally, Prof W Van Schaik
Applications accepted all year round

Funding Type

PhD Type

Increasing antibiotic resistance in bacterial infections is a serious threat to modern medicine, so understanding why some bacteria become resistant to multiple antibiotics whereas others do not is an important challenge for microbiologists, doctors and vets.
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  The role of pore-forming bacterial proteins in pneumonia and meningitis
  Prof T J Mitchell, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

The bacterium Streptococcus pneumoniae (the pneumococcus) is carried in the nasopharynx of most children and some adults without causing disease.
  Understanding and combatting antimicrobial resistance plasmids
  Dr M Buckner, Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is a major crisis for human medicine. Globally, untreatable bacterial infections are rapidly increasing, leaving us with limited treatment options.
  Build and destroy: investigating targeted protein degradation in plant development and stress-response
  Dr D Gibbs
Applications accepted all year round

Funding Type

PhD Type

In order to effectively co-ordinate their growth and development, plants need to be able to respond to changes in their environment, whether it is adapting to the seasons or coping with stresses.
  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  Discovering molecular genetic mechanisms of central nervous system regeneration
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

Is it possible to promote regeneration of the central nervous system after injury, damage or disease? During normal development, neutrons and glia interact to coordinate the generations of neutrons and glia, and direct cell migration patterns, axonal navigation, dendritic arborisation and the emergence of neural circuits.
  Epigenetic contribution to grafting induced vigour in Solanaceous plants
  Dr M Catoni
Application Deadline: 7 June 2020

Funding Type

PhD Type

Grafting is a long-standing agronomical method used to improve plants production since more than 4000 years ago, consisting in physically joining two plants together, generally referred as rootstock (part below the ground) and scion (part above the ground).
  Genetic analysis of the bacterial translocation machinery
  Dr D Huber
Applications accepted all year round

Funding Type

PhD Type

Every subcellular compartment in a cell contains proteins, and yet all of these proteins are initially synthesised in the same compartment.
  How does heterosis affect yield, quality and disease resistance in hybrid wheat?
  Dr P Borrill, Dr M Catoni, Dr C Uauy, Dr N Bird
Application Deadline: 7 June 2020

Funding Type

PhD Type

Heterosis, or hybrid vigour, is the increased performance of a hybrid relative to the parents. The use of hybrid cultivars in maize and rice have increased the performance of these crops substantially, but the same approach has not yet been widely exploited in wheat breeding.
  Molecular and genetic mechanisms of brain structural plasticity and neurodegeneration in the fruit-fly Drosophila.
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The brain changes throughout life. brain plasticity enables the brain to adjust in response to experience, whereas during aging natural neurodegeneration takes over.
  Molecular Cookie Cutters: Cutting Edge Drug Discovery using G-Protein Coupled Receptors
  Prof T R Dafforn
Application Deadline: 7 June 2020

Funding Type

PhD Type

Membrane proteins represent 30-40% of the cellular proteome and carry out a wide range of fundamental biological process. These include sensing the outside world, helping maintain cellular structure and homeostasis.
  Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage.
  Understanding signalling networks underpinning key developmental processes during plant evolution
  Research Group: BBSRC MIBTP
  Dr J C Coates
Applications accepted all year round

Funding Type

PhD Type

Plants first appeared on land almost half a billion years ago. All land plants likely evolved from a single aquatic green algal ancestor.
  Dynamics of Foam Flow Through Processing Equipment
  Prof M Barigou
Application Deadline: 31 July 2020

Funding Type

PhD Type

Gas-liquid foams are structured two-phase fluids in which gas bubbles are separated by interconnecting thin liquid films, and the volume fraction of the continuous liquid phase is small in dry foams but can be substantial in wet foams.
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