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University of Cambridge PhD Projects

We have 27 University of Cambridge PhD Projects

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Showing 1 to 27 of 27
  A genome-wide view of posttranscriptional processes
  Dr J Mata
Applications accepted all year round

Funding Type

PhD Type

A typical yeast cell contains around 40,000 molecules of messenger RNA (mRNA), whereas a typical mammalian cell more than 100,000.
  Alternative pre-mRNA splicing
  Prof C W J Smith
Applications accepted all year round

Funding Type

PhD Type

The following is a general statement about ongoing research on alternative splicing in the Smith lab. Specific projects will be available in one or more of these areas.
  Evolution and biochemistry of photosynthesis - electron transfer reactions, renewable energy production, biotechnology, and chloroplast genomes
  Prof C J Howe
Applications accepted all year round

Funding Type

PhD Type

The common theme of our work is the biochemistry and evolution of photosynthesis.
  Mechanism of transmembrane receptor activation
  Dr M Hyvonen
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a PhD position, starting in October 2019, in the group Dr Marko Hyvonen at University of Cambridge (http://hyvonen.bioc.cam.ac.uk/) to study the mechanism of transmembrane signalling by TGFbeta family growth factors.
  Molecular mechanism of innate immunity mediated by the Toll/IL1 receptor signalling pathways.
  Prof N J Gay
Applications accepted all year round

Funding Type

PhD Type

This group participates in the Wellcome Trust 4 year PhD programme in Developmental biology., MRC and BBSRC Doctoral Training Programmes.
  Regulation of virulence and biofilm formation by quorum sensing and the "stress alarmone" ppGpp in gram-negative pathogenic bacteria.
  Dr M Welch
Applications accepted all year round

Funding Type

PhD Type

We are investigating the complex interplay between cell-cell signalling (quorum sensing), microbial lifestyle (i.e., free-living planktonic cultures vs sessile biofilm communities), growth phase and virulence in gram-negative bacteria.
  Small G proteins and their effectors as therapeutic targets in cancer
  Dr D Owen
Applications accepted all year round

Funding Type

PhD Type

For the majority of cancers the acquisition of invasive and metastatic characteristics leads to incurable disease in the host.
  Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins
  Dr H Mott
Applications accepted all year round

Funding Type

PhD Type

Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Developing Synthetic Models of the Cochlea to Investigate Cochlear Implant Stimulation Spread
  Prof M Bance
Application Deadline: 3 December 2019

Funding Type

PhD Type

(PhD- suitable for engineering, materials, chemical engineering and biomedical backgrounds). (co-supervised by Professor George Malliaras, Dr Debi Vickers and Dr Bob Carlyon).
  Development and Application of Novel PET Markers of Neuroinflammation
  Dr F Aigbirhio
Application Deadline: 3 December 2019

Funding Type

PhD Type

This project’s objective is to develop novel in vivo PET probes for application as sensitive markers of neuroinflammatory processes which are key components of several pathologies, including stroke, traumatic brain injury, multiple sclerosis and dementias.
  Does Histone Deacetalyse Inhibition Reduce Atherosclerosis and Stroke Risk (PhD only) 
  Prof H Markus
Application Deadline: 3 December 2019

Funding Type

PhD Type

The Cambridge Stroke Group led the identification of the HDAC9 (histone deacetalyse 9) gene as a risk factor for stroke. The association is specific for large artery stroke due to atherosclerosis.
  Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology
  Dr E Avezov
Application Deadline: 3 December 2019

Funding Type

PhD Type

The Endoplasmic Reticulum (ER) is a multifunctional organelle, shaped as a contiguous network of membranous pipes extending throughout the cell periphery.
  Functional MRI Imaging in Traumatic Brain Injury
  Dr E Stamatakis
Application Deadline: 3 December 2019

Funding Type

PhD Type

CENTER-TBI is a large European project that aims to improve the care for patients with Traumatic Brain Injury (TBI). The work undertaken in Cambridge will examine the role of MRI in routine TBI imaging and this project will focus on the role of resting state functional MRI in TBI imaging.
  Investigating the Immune Basis of Parkinson’s Disease (PhD only)
  Dr C Williams-Gray
Application Deadline: 3 December 2019

Funding Type

PhD Type

It is now well established that immune activation occurs in Parkinson’s disease, but whether it plays a critical role in disease onset and progression remains uncertain.
  Making Induced Neural Stem Cells from People with Progressive Multiple Sclerosis
  Dr S Pluchino, Dr A Nicaise
Application Deadline: 3 December 2019

Funding Type

PhD Type

Multiple sclerosis (MS), an immune-mediated disease of the central nervous system, afflicts an estimated 2-3 million people worldwide, most of whom will ultimately develop a progressive form of the disease with few therapeutic options.
  Methodology of Clinical Tests for Assessment of Cerebral Autoregulation after Traumatic Head Injury
  Prof M Czosnyka
Application Deadline: 3 December 2019

Funding Type

PhD Type

Various methods exist for assessment of autoregulation of Cerebral Blood Flow (CBF). They incorporate different modalities. arterial blood pressure, intracranial pressure, blood flow velocity, cerebral perfusion pressure, and brain tissue oxygenation (1).
  Mitochondrial DNA Mutations and Human Disease
  Prof P Chinnery, Dr R Horvath
Application Deadline: 3 December 2019

Funding Type

PhD Type

Mutations of mitochondrial DNA (mtDNA) are a major cause of inherited diseases and contribute to neurodegeneration. Many are heteroplasmic, with a mixture of mutated and wild-type genomes.
  Mitochondrial Genetics and Inherited Eye Diseases
  Dr P Yu-Wai-Man
Application Deadline: 3 December 2019

Funding Type

PhD Type

My research group is focused on new gene discovery and we are using a multipronged approach to dissect the disease pathways contributing to progressive neuronal loss and blindness, including zebrafish models and patient-derived induced pluripotent stem cells.
  Modelling of Diffusion Weighted MRI
  Dr G Williams
Application Deadline: 3 December 2019

Funding Type

PhD Type

Recent methodological advances in diffusion weighted MRI allows for more complex modelling of anatomical parameters.
  Progression in Neurodegenerative Tauopathies: Neuroimaging Biomarkers and Disease Models
  Dr J Rowe, Dr T Rittman
Application Deadline: 3 December 2019

Funding Type

PhD Type

One of the challenges in understanding neurodegenerative disorders is to relate the effect of genetic and molecular changes associated with disease to the level of the whole brain.
  Studying the Molecular Mechanism of Mitochondrial Aminoacyl tRNA Synthetases in Neurons
  Dr R Horvath, Prof P Chinnery
Application Deadline: 3 December 2019

Funding Type

PhD Type

Aminoacyl-tRNA synthetases (ARSs) are essential and ubiquitous ‘house-keeping’ enzymes responsible for charging amino acids to their cognate tRNAs and provide the substrates for global protein synthesis in the cytosol and mitochondria.
  Predicting tuber dry matter concentration in potato
  Dr M Stalham, Prof H Griffiths
Application Deadline: 4 October 2019

Funding Type

PhD Type

Supervisors. Dr Mark Stalham (NIAB CUF), Prof. Howard Griffiths (University of Cambridge). The dry matter concentration of potato tubers is an important quality attribute, particularly for the production of crisps and french fries but also for fresh produce.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round

Funding Type

PhD Type

This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
  Pathophysiology of red cell membrane permeability
  Dr J Gibson
Applications accepted all year round

Funding Type

PhD Type

Our project investigates how red cell membrane permeability is altered in pathophysiological states.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  Evolution of Influenza Viruses - prediction of possible future antigenic variants
  Prof D Smith
Application Deadline: 2 January 2020

Funding Type

PhD Type

Evolution of Influenza Viruses. Centre for Pathogen Evolution. Department of Zoology. University of Cambridge. Project summary. Our research focus is to design and develop analytical, computational, and mathematical methods to understand the fundamental processes that govern the evolution of influenza viruses.
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