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Physical Chemistry (structural biology) PhD Projects, Programs & Scholarships

We have 18 Physical Chemistry (structural biology) PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Electron Paramagnetic Resonance Pulsed Dipolar Spectroscopy for Structural Biology
  Dr A Bowen, Dr S Hay, Dr M Shanmugam
Application Deadline: 31 January 2020

Funding Type

PhD Type

Electron Paramagnetic Resonance is a rapidly expanding suit of techniques used for the study of complex (bio)molecules that possess spin-active moieties with unaired electrons.
  (BBSRC DTP CASE) Design of a light-driven biocatalyst
  Prof D Leys, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

Illumination is able to unlock a wide range of photochemical reactions, but light is rarely used by living organisms. In fact, to date only three light dependent enzymes have been described in detail.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  (BBSRC DTP) In silico enzymology: A mechanistic study of prenylated flavin-dependent enzymes
  Dr S Hay, Prof D Leys
Application Deadline: 31 January 2020

Funding Type

PhD Type

Many enzymes make use of cofactors to aid in catalysis, as they offer alternative reactivities to the canonical amino acids found in the enzyme active site.
  Assessing the Behaviour of Endotoxin in Biopharmaceutical Formulations: towards creating improved medicines
  Dr A Golovanov
Application Deadline: 15 November 2019

Funding Type

PhD Type

Supervisors. Dr Alexander Golovanov (The University of Manchester) and Dr Adrian Podmore (AstraZeneca). Biopharmaceuticals are the fastest-growing type of treatments for wide range of diseases, with enormous potential for personalised medicine.
  Molecular approaches to modulate antibody receptor signalling in autoimmunity
  Dr J Robinson, Prof A Morgan
Application Deadline: 13 January 2020

Funding Type

PhD Type

Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  Next-generation protein engineering: integration of ab-initio modelling, high-throughput screening and structural fingerprinting by mass spectrometry.
  Research Group: BBSRC White Rose DTP
  Dr E Paci, Dr D Tomlinson, Prof F. Sobott
Application Deadline: 6 January 2020

Funding Type

PhD Type

Recombinant proteins are playing an ever-increasing role as therapeutics and reagents in biotechnology. Rationally engineering proteins requires understanding of the principles behind protein interactions.
  Observing Nucleic Acid Aptamer Binding with Ultrafast 2D-IR Spectroscopy
  Prof N Hunt
Application Deadline: 8 January 2020

Funding Type

PhD Type

The project will be a collaboration with Prof Glenn Burley (University of Strathclyde). Background. The strong and specific binding of small molecules and proteins to DNA has relevance across many areas, from fundamental biophysics, through chemical biology to nanotechnology.
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