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We have 9 Physiology (biochemical) PhD Projects, Programmes & Scholarships

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Physiology (biochemical) PhD Projects, Programmes & Scholarships

We have 9 Physiology (biochemical) PhD Projects, Programmes & Scholarships

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle

  Research Group: Chemistry and Biosciences
APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is thought to involve the endothelial protein C receptor (EPCR) and a protease activated receptor (PAR). Read more

Neuronal control of appetite: investigating the role of the extracellular matrix in controlling neuronal activity in the hypothalamus

  Research Group: Chemistry and Biosciences
Appetite regulation is complex, and its dysregulation has serious implications for health, being observed in multiple conditions e.g., obesity, anorexia, and type 2 diabetes. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

How does SUMOylation regulate cell survival and death in Heat Shock Response?

Heat shock response (HSR) is a universally existing essential phenomenon for all living organisms to survive sudden increases in environmental temperature that have pronounced damaging effects on important cellular structures and functions (1). Read more
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