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We have 18 Physiology (genetic) PhD Projects, Programmes & Scholarships

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Physiology (genetic) PhD Projects, Programmes & Scholarships

We have 18 Physiology (genetic) PhD Projects, Programmes & Scholarships

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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health
Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more
 Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more
 Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Funded PhD - Determining the genetic and circadian basis of bipolar disorder

University of Bristol School of Physiology, Pharmacology & Neuroscience
This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more
 Supervisors: Prof J Hodge, Dr AF French
 12 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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MScR - Determining the genetic and circadian basis of bipolar disorder using Drosophila

University of Bristol School of Physiology, Pharmacology & Neuroscience
Circadian rhythms and sleep are evolutionarily conserved from fruit flies (Drosophila) and are fundamental as well as vital to biology and health (Jagannath et al., 2017; Menet and Rosbash, 2011). Read more
 Supervisor: Prof J Hodge
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health
Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
 Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Disease modelling to understand long-term progression and treatment response in Spinal Muscular Atrophy and Duchenne Muscular Dystrophy.

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships
This project addresses the urgent medical need to collect and analyse big data sources. on the natural history disease progression of children with Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD). Read more
 Supervisors: Dr G Baranello, Dr D Ridout
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more
 Supervisor: Dr JH Hughes
 10 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Exploring tyrosine metabolism as a source of oxidative stress

University of Liverpool Institute of Life Course and Medical Sciences
We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress associated with tyrosine metabolism. Read more
 Supervisors: Dr BN Norman, Dr JH Hughes, Prof L Ranganath
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Targeting the sweet tooth to curb population-wide sugar intake

University of Nottingham School of Medicine
Excess intake of dietary sugars are a major contributor to obesity, and type 2 diabetes and 82% of people state that taste is the major determinant of what they buy and eat. Read more
 Supervisor: Dr P Aldiss
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics
Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more
 Supervisor: Dr RB Burton
 1 July 2024  PhD Research Project  Self-Funded PhD Students Only
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SLS SF3: PhD in Pharmacological intervention of ion channels for the treatment of cardiac disease

University of Westminster School of Life Sciences
Within our lab we study human ion channels, mainly potassium channels, that contain genetic mutations which lead to disease states. Read more
 Supervisors: Dr KP Cunningham, Dr S Getting, Dr DG Gaze
 17 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Molecular mechanisms of the increase in maximal aerobic capacity (VO2max) with regular exercise

University of Stirling Faculty of Health Sciences and Sport
  Research Group: PENRG - Physiology Exercise and Nutrition Research Group
Performing regular exercise is crucial for good health and wellbeing, whereas failing to perform sufficient exercise increases the risk of diseases such as cardiovascular disease, type 2 diabetes, cancer, etc. Read more
 Supervisors: Dr N Vollaard, Dr ECR Hall
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of oxidative metabolites in joint destruction in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences
We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress in alkaptonuria (AKU) and associated conditions. Read more
 Supervisors: Dr BN Norman, Dr JH Hughes, Prof G Bou-Gharios
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies

University of Bristol School of Physiology, Pharmacology & Neuroscience
Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more
 Supervisor: Prof J Hodge
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Role of the endosomal pathway in regulating sleep and circadian rhythms

University of York York Biomedical Research Institute
Ageing and many neurodegenerative disorders are characterised by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more
 Supervisors: Dr S Chawla, Dr S Sweeney
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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