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We have 5 Physiology (liver) PhD Projects, Programmes & Scholarships

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Physiology (liver) PhD Projects, Programmes & Scholarships

We have 5 Physiology (liver) PhD Projects, Programmes & Scholarships

Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity

Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Read more

Targeting the sweet tooth to curb population-wide sugar intake

Excess intake of dietary sugars are a major contributor to obesity, and type 2 diabetes and 82% of people state that taste is the major determinant of what they buy and eat. Read more

Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more

Preclinical testing of collagen synthesis inhibitors for fibrotic disease

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
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