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Physiology & Sports Science (skeletal muscle) PhD Projects, Programs & Scholarships

We have 11 Physiology & Sports Science (skeletal muscle) PhD Projects, Programs & Scholarships

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  The effects of mechanical and electrical stimulation on the maturity of tissue engineered skeletal muscle
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

Skeletal muscle undergoes hypertrophy in response to exercise and mechanical loading, however although this response is well studied and established, the molecular sensors and signaling pathways which produce this response are not fully elucidated.
  A multi-tissue in vitro model of osteoarthritis
  Prof M.P. Lewis, Dr D Player
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) is a joint disorder which is predominantly found in elderly individuals (Lee et al., 2013), but has recently been linked to sports participation at high levels (Vannini et al., 2016).
  Vascularisation of tissue engineered skeletal muscle
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

Tissue engineering strategies have created a large number of functional tissues constructed from cells and matrix components over the past two decades.
  Cellular mechanisms of detrimental skeletal muscle remodeling induced by cardiac dysfunction
  Dr T.S. Bowen, Dr D Steele
Application Deadline: 14 June 2020

Funding Type

PhD Type

The loss of skeletal muscle mass and strength is a key impairment in many disease states. This occurs in both limb and respiratory muscles and leads to pulmonary complications and severe disability.
  RVC PhD: Rebalancing mitochondrial metabolism in Duchenne Muscular Dystrophy - a novel therapeutic avenue?
  Dr C Thornton, Prof D Wells
Application Deadline: 9 February 2020

Funding Type

PhD Type

Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disease caused by mutations in the DMD gene that lead to the loss of a functional version of the subsarcolemmal protein dystrophin.
  Gene and Cell Therapy For Muscular Dystrophy, Muscular Atrophy, Diabetes and Metabolic conditions
  Dr K Foster
Applications accepted all year round

Funding Type

PhD Type

Skeletal muscle development is a complex process and a number of regulatory factors for the different steps involved in stem cell activation and proliferation through to multinucleated, post-mitotic cells have been identified.
  Using a novel 3D co-culture model to define metabolic flux maps of different cancer cell types in response to physical activity
  Dr M Morris, Dr A Islam, Prof M.P. Lewis
Applications accepted all year round

Funding Type

PhD Type

During exercise, and in the presence of sufficient oxygen, glucose is metabolised by muscle cells to produce pyruvate, a metabolic intermediate which is fed into the Kreb’s cycle in the mitochondria to produce large amounts of energy.
  Sex hormone actions in frailty and health during ageing
  Dr M Garratt
Applications accepted all year round

Funding Type

PhD Type

It is well established that testosterone and estrogens can influence ageing, with hormone administration improving physical function, muscle and bone strength in some cohorts of the elderly.
  Sex differences of ultra-endurance running: Profiling of female ultra-runners
  Dr H Moir
Applications accepted all year round

Funding Type

PhD Type

Ultra-endurance running has become increasingly popular, both in amateur and recreational athletes, with an exponential increase in the number of ultra-marathon finishers between 1998 and 2011 (Cejka et al., 2013; Hoffman & Krishnan 2013;).
  Two pore channel segment 2: a new partner in crime for the AMPK-mTORC1 signalling pathway
  Prof A M Evans
Applications accepted all year round

Funding Type

PhD Type

We were the first to demonstrate that two pore segment channels (TPC1-3) represent a family of calcium release channels that are preferentially targeted to endolysosomes.
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