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PhD Projects, Programs & Scholarships in Prague

We have 37 PhD Projects, Programs & Scholarships in Prague

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  PhD Positions at IOCB Prague Call for Applications 2020

Funding Type

PhD Type

IOCB Prague is looking for talented, independent and highly motivated students with an MSc degree or equivalent in life sciences or related fields.
  Application of metallo-DNA in nanoelectronics
  Dr V Sychrovsky
Application Deadline: 23 February 2020

Funding Type

PhD Type

Incorporation of metals such as Hg(II) and Ag(I) into DNA leads to novel base pairs. They fit in canonical DNA duplex, and the metal array is shielded from the solvent.
  Cathepsin proteases in biomedicine
  Dr M Mareš
Application Deadline: 23 February 2020

Funding Type

PhD Type

The project is focused on proteolytic enzymes of the cathepsin type that are critically involved in pathologies and are therapeutic targets.
  Chemical biology tools for drug development
  Dr J Konvalinka, Dr P Sacha
Application Deadline: 23 February 2020

Funding Type

PhD Type

Laboratory of Jan Konvalinka looks for a PhD candidates to work on development of several novel chemical biology tools for drug design, target discovery and validation, compound screening and target protein visualization.
  Chemical or enzymatic labelling of epigenetic nucleobases in DNA
  Prof M Hocek
Application Deadline: 23 February 2020

Funding Type

PhD Type

New biocompatible chemical or enzymatic reactions will be studied and developed for modification of epigenetic bases (e.g. 5hmC, 5hmU, 5fC, etc.).
  Chemical synthesis of hypermodified oligonucleotides and DNA
  Prof M Hocek
Application Deadline: 23 February 2020

Funding Type

PhD Type

Chemical synthesis of hypermodified oligonucleotides and DNA stretches will be studied and developer using novel base-modified nucleoside phosphoramidites.
  Computational modelling of molecular optical activity
  Prof P Bour
Application Deadline: 23 February 2020

Funding Type

PhD Type

Spectroscopic methods using optical activity provide unique information about molecular structure and behavior. The interpretation of such spectra, however, is a challenging process, typically involving a combination of molecular dynamics and quantum chemical computations.
  Design and synthesis of novel photoswitches derived from bisazobenzenes
  Dr Z Janeba
Application Deadline: 23 February 2020

Funding Type

PhD Type

We have recently reported the synthesis of suitable substituted 5-phenylazopyrimidines (see selected references for more information).
  Development of chemical tools to study and manipulate biological processes in live cells
  Dr M Vrábel
Application Deadline: 23 February 2020

Funding Type

PhD Type

Chemical reactions compatible with biological systems offer unique possibility to manipulate and study biological processes under native conditions.
  Development of machine learning algorithms for the prediction of terpene synthase activity
  Dr T Pluskal
Application Deadline: 23 February 2020

Funding Type

PhD Type

Bioactive plant metabolites are an essential source of chemical scaffolds for the development of new medicines. Our group is interested in establishing new cutting-edge methods to harness the biosynthetic potential of plant specialized metabolism for the benefit of human health.
  Development of methods for stabilization of organic radicals
  Dr T Slanina
Application Deadline: 23 February 2020

Funding Type

PhD Type

Organic radicals and radical ions represent an interesting class of open-shell molecules that are relevant in the design of molecular electronics and systems for light energy conversion and storage.
  Development of systems for reversible electron transfer
  Dr T Slanina
Application Deadline: 23 February 2020

Funding Type

PhD Type

Electron transfer and charge separation are some of the most important phenomena in the Universe. It plays an important role in processes essential for life, such as photosynthesis, respiration, protein folding, and biocatalysis.
  Elucidation and engineering of the biosynthetic pathways of unique diterpenoids
  Dr T Pluskal
Application Deadline: 23 February 2020

Funding Type

PhD Type

Bioactive plant metabolites are an essential source of chemical scaffolds for the development of new medicines. However, their complex chemical structures and intricate stereochemistry often render their chemical synthesis unfeasible.
  Enantioselective catalysis under the control of helical chirality
  Dr I Starý
Application Deadline: 23 February 2020

Funding Type

PhD Type

The goal of the PhD project will be the development of new helically chiral ligands and metal complexes to be explored in enantioselective catalysis.
  Exploring the fundamental molecular interactions modulating glycocalyx bioactivity
  Dr H Martinez-Seara Monne
Application Deadline: 23 February 2020

Funding Type

PhD Type

Glycocalyx or extracellular matrix is a charged thick layer of biomacromolecules, which is bound to the membrane at the cell surface.
  Hijacking of human host factors by viruses
  Dr E Boura
Application Deadline: 23 February 2020

Funding Type

PhD Type

Space in the capsids of small viruses is limited and small viruses do not encode every enzymatic activity required for their replication.
  Investigating customised functional molecules by the state-of-the-art cryogenic scanning probe microscopy
  Dr I Starý, Dr M Švec
Application Deadline: 23 February 2020

Funding Type

PhD Type

You will be given the chance to discover and map the character of custom-created organic molecules using a very special type of scanning probe microscope working at cryogenic temperatures with picometer precision.
  Lanthanide Circularly Polarized Luminescence Probes of DNA Structure
  Dr V Andrushchenko
Application Deadline: 23 February 2020

Funding Type

PhD Type

Circularly polarized luminescence (CPL) of lanthanides is sensitive to the local molecular environment, which can be used in biomolecular science.
  Liquid nebulization in ion sources for mass spectrometry
  Dr J Cvacka
Application Deadline: 23 February 2020

Funding Type

PhD Type

Mass spectrometry is a powerful analytical technique used to identify and quantify compounds by means of the mass-to-charge ratio of ions produced from a sample.
  Metabolic engineering of novel kavalactones using yeast quiescent cells
  Dr T Pluskal
Application Deadline: 23 February 2020

Funding Type

PhD Type

Metabolic engineering is a modern approach for the production of high-value molecules using enzymatic biosynthetic systems, typically expressed in microbes.
  Modified nucleoside triphosphates with unnatural nucleobases for enzymatic synthesis of modified DNA
  Prof M Hocek
Application Deadline: 23 February 2020

Funding Type

PhD Type

The project will deal with the study and development of the chemical synthesis of diverse modified nucleoside triphosphates derived from d5SICS and dMMO2 nucleosides, which are used in the extension of the genetic alphabet.
  Molecular Machines in Supramolecular Systems
  Dr J Kaleta
Application Deadline: 23 February 2020

Funding Type

PhD Type

Molecular machines, particularly their 2-D and 3-D assemblies, are unique systems with huge potential in nanoelectronics.
  Nanoparticles for elimination of viruses spreading through air, water and bodily fluids
  Dr J Weber
Application Deadline: 23 February 2020

Funding Type

PhD Type

Proposed PhD project addresses the problem of the threat of viruses in the environment to the public.
  New RNA modifications for regulation of translation
  Prof M Hocek
Application Deadline: 23 February 2020

Funding Type

PhD Type

New types of modified mRNA bearing diverse substituents at nucleobases will be prepared by polymerase incorporation of modified nucleoside triphosphates and the influence of these non-natural substituents on interactions with proteins as well as on translation will be studied.
  Nonplanar unconventional pi-electron systems
  Dr I Stará
Application Deadline: 23 February 2020

Funding Type

PhD Type

The project is focused on the synthesis of extended (hetero)helicenes, bi(hetero)helicenes, (hetero)cycloarenes and reactivity of helicene pyridazines.
  Nucleotides bearing polar or charged functional groups for enzymatic synthesis of modified DNA
  Prof M Hocek
Application Deadline: 23 February 2020

Funding Type

PhD Type

New nucleosides and nucleoside triphosphates bearing polar or charged functional groups (e.g. acidic or basic groups, cationic or anionic substituents, etc.) will be designed and synthesized.
  Role, biogenesis, and biodegradation of NpnN RNA caps in prokaryotes
  Dr H Cahová
Application Deadline: 23 February 2020

Funding Type

PhD Type

Recent discovery of RNA caps such as NAD and CoA leads to reassessment of RNA structure in all types of cells. In our search for new RNA modifications, we have discovered brand new class of 5‘caps – dinucleoside polyphosphates (NpnN) in bacteria.
  Spectroscopic Studies of Protein Fibrils
  Prof P Bour
Application Deadline: 23 February 2020

Funding Type

PhD Type

Insoluble proteins aggregates, "fibrils", posses interesting properties and occur in many biological processes. Understanding their behavior may help to limit some neurodegenerative diseases (Parkinson, Alzheimer, mad cow...).
  Spectroscopic studies of sugar-lectin interactions
  Dr J Kaminsky
Application Deadline: 23 February 2020

Funding Type

PhD Type

Lectins are carbohydrate-binding proteins that control various functions in living organisms including the cell-cell interaction, inflammatory and immune response, fertilization, adhesion and virulence of pathogens.
  Surface-Mounted Molecular Motors
  Dr J Kaleta
Application Deadline: 23 February 2020

Funding Type

PhD Type

Organizing of individual molecular machines into regular 2-D assemblies is a promising route towards a new generation of smart materials.
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