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Institute of Cancer Sciences

Institute of Cancer Sciences
Self-Funded PhD Opportunties

The Institute of Cancer Sciences is part of a national centre of excellence in the fight against cancer. We carry out a programme of world-class science directed at understanding the molecular changes that cause cancer. We are working to translate scientific discoveries into new drugs or diagnostic and prognostic tools that benefit cancer patients, taking new therapies through preclinical and clinical trials.


Institute of Cancer Sciences

Self-Funded PhD Opportunities

Evaluation of combination therapies targeting DNA damage repair signalling pathways in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive cancer affecting mostly adult and elderly patients. It has a very poor 5-year survival of <20% in the UK. In this project we wish to further evaluate histone demethylase inhibitors as single agents or in combination with DDRi in primary patient blasts to inform future clinical trial design.

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Investigating the role of autophagy and mitochondrial function in leukaemic stem cells
Our lab is interested in biological processes that contribute to drug resistance in myeloid leukaemias, with particular focus on leukaemic stem cells (LSCs). This project will therefore promote identification of a core fuel pathway signature of CML/AML LSCs and a set of new potentially selective LSC-specific metabolic drug targets. The student will also use state-of-the-art in vitro and in vivo models to test clinically relevant drugs, which will in the longer term, facilitate the translation of our findings into the clinic, with the overall aim for CML and AML LSC eradication.

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Investigating the signalling processes that determine directional glioblastoma cell migration
Glioblastoma (GBM) is the most common and aggressive primary brain tumour, and currently has a median survival of approximately 15 months. This project will utilise a range of advanced imaging techniques (multiphoton, super resolution etc) to interrogate these processes in sophisticated in vitro and in vivo models of GBM that are available at the Institute of Cancer Sciences, under the guidance of extensive local expertise.

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Understanding and exploiting immunogenic cell death to treat cancer
Cell death both prevents and treats cancer. New anti-cancer therapies that directly target cell death are revolutionising the treatment of cancer. This PhD project will seek to understand why such caspase-inhibited cell death is immunogenic - both at the level of the dying cell but also in understanding how the immune system responds to the dying cell.

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