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School of Veterinary Medicine

School of Veterinary Medicine
Self-Funded PhD Opportunities

The University of Glasgow’s School of Veterinary Medicine is renowned for teaching, research and clinical provision, and attracts students, researchers and clinicians from around the world. The internationally accredited school provides expert referral services via the Small Animal Hospital, the Glasgow Equine Hospital and Practice and the Scottish Centre for Production Animal Health & Welfare alongside a full range of Veterinary Diagnostic Services for animal owners and referring practitioners throughout the UK and beyond.


School of Veterinary Medicine

Self-Funded PhD Opportunities

Transgenerational consequences of exposure to chemical mixtures on reproductive and metabolic health
The effects of chronic exposure to a complex mixture of chemicals such as that which exists within our environment is poorly understood. Much of the existing research has focused on acute pharmacological exposure, to single chemicals, in altricial animal models, often only in a single sex. We have developed a unique, more appropriate model, with which to investigate the effects of in utero exposure to a real-life mixture of chemicals in longer lived outbred mammals, the biosolids exposed sheep model. Biosolids are derived from the solid waste generated in wastewater treatment plants therefore contains a chemical load that reflects the normal human exposome. Biosolids are routinely used as an agricultural fertilizer and when animals are grazed on biosolids treated pasture, they are exposed to our exposome. We have already shown that when pregnant sheep are grazed on biosolids treated pasture their offspring show alterations in thyroid, liver and gonadal function, bone development and behaviour. Using this model, this project will contribute to investigation of the longitudinal effects of exposure to a chemical mixture during in utero development, on the reproductive and metabolic health of F1, F2 and F3 offspring. The project will use a combination of in vivo animal based interventional and observational studies e.g. timing of puberty, glucose tolerance tests and ex vivo investigation of physiological function using immunohistochemical and molecular biological approaches.

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