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The Radcliffe Department of Medicine Four Year PhD Scholars Programme

Image credit: Martin Phelps

The Radcliffe Department of Medicine Four Year PhD Scholars Programme

The Radcliffe Department of Medicine at the University of Oxford is a large, multi-disciplinary department, which aims to tackle some of the world’s biggest health challenges by integrating innovative basic biology with cutting edge clinical research.

The department has internationally renowned programmes in a broad spectrum of sciences related to medicine, including:

  • Cancer Biology
  • Cardiovascular Science
  • Cellular and Clinical Imaging
  • Computational Biology
  • Diabetes, Metabolism and Endocrinology
  • Genetics and Genomics
  • Haematology and Pathology
  • Immunology
  • Stem Cells and Developmental Biology
The Radcliffe Department of Medicine Four Year PhD Scholars Programme

Image credit: Martin Phelps

Our research spans the translational research spectrum, from basic biological research through to clinical application. A full list of supervisor profiles can be found below.

Our PhD Scholars Programme is open to outstanding candidates of any nationality. It provides fully-funded awards for students wishing to undertake a four year PhD in Medical Sciences.

Further details on the application process are available on the RDM website. We encourage applicants to contact their prospective supervisors to discuss projects and their suitability to carry out research in advance of application.

The closing date for applications is 12 noon (midday) on 11th January 2019.

Interviews will take place during the week commencing 28th January 2019.

Offers will be made in February 2019.

The Radcliffe Department of Medicine actively promotes a family friendly working environment.

Projects

Academic Endocrine Unit: investigating the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.Details
Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteinsDetails
Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.Details
Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human diseaseDetails
Circadian control of energy metabolism and inflammation: Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biologyDetails
Clinical Genetics: Building the skull – normal and abnormal developmentDetails
Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testisDetails
Development of Gene Therapy and Gene Editing for Lung Disorders: the translation of new gene therapies to the clinic, including the development of new vectors, and evaluation in animal models of disease.Details
Development of the hematopoietic/ immune system in the embryo: obtaining a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic developmentDetails
Functional coronary artery disease genetics: investigating the role of the candidate gene in models of In vivo cardiovascular diseaseDetails
Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseasesDetails
Gene Regulatory Networks in Development and Disease: Focusing on systems level “big picture” approaches to understand gene regulation and build gene regulatory networks during development and disease in zebrafish, chick, lamprey and human models.Details
Genetics and Genomics of Type 2 Diabetes: using human genetics to drive a mechanistic understanding of type 2 diabetes and to identify novel translational opportunitiesDetails
Genetics of inherited cardiovascular disease: Using molecular genetic analysis of cardiovascular disease as a tool to define disease mechanisms and therapeutic targets.Details
Genome Engineering and Synthetic Biology: Design and implementation of synthetic circuits for research and therapeutic applications.Details
Genomics of Diabetes: Functional characterisation of T2D GWASDetails
Genomics, gene regulation and disease: How human genome variation affects gene expressionDetails
Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human diseaseDetails
Go with the flow: the why and how of cardiovascular diseaseDetails
Haematopoietic Stem Cell Biology: Understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignanciesDetails
Human fat distribution and metabolic disease: Identifying the mechanistic basis for site-specific fat storage to identify new ways of tackling the metabolic consequences of obesity.Details
Human liver fat metabolism and metabolic disease: Understanding the underlying causes and mechanistic basis for intrahepatic fat storage to identify ways of preventing and treating fatty liver disease.Details
Imaging in Preventive Cardiology Research: improving how we identify and prevent heart disease in young peopleDetails
Iron and Immunity: studying how iron and anaemia influence immunity and infectious diseasesDetails
Molecular dissection of blood cell fate determination: identifying key principles in the control of cell fate decisionsDetails
Molecular nano-immunology and optical microscopy: the application and development of ultra-sensitive, live-cell fluorescence microscopy techniques with a spatial resolution down to the molecular levelDetails
Molecular pathogenesis of the myelodysplastic syndromes: investigation of the molecular mechanisms involved in disease initiation and progression in the myeloid malignancy myelodysplastic syndromes (MDS)Details
Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillationDetails
Myocardial functional T1 mapping – Advanced cardiac magnetic resonance imaging techniques: improving and standardization of quantitative CMR approaches to support better healthcareDetails
Normal and Leukaemic Haemopoiesis: Understanding the fundamental biological processes underlying normal and malignant haematopoiesis and translate this to improve patient outcomes through new rational therapies.Details
Nucleic Acid Sensing: Investigating the molecular biology of activation and regulation of innate immune receptors that survey the cytosol, using a variety of virus infection models including influenza A virus, HIV and other retroviruses, flaviviruses such as Zika virus, and herpes viruses.Details
T Cell Biology: Studying how lymphocytes decide to mount immune responses against, for example, tumours (cancer immunotherapy).Details
Trained innate immunity in atherosclerosis: interrogating human tissue using state of the art “-omics” approachesDetails
Translational Cardiovascular Research, Cross-talk between adipose tissue and the cardiovascular system in humansDetails
Tumour microenvironment and colorectal cancer development: understanding the mechanisms of the tumour growthDetails
Understanding and Treating Metabolic Liver Disease: Understanding the causes of non-alcoholic fatty liver disease to identify new biomarkers of disease stage as well as trial novel treatmentsDetails
The Radcliffe Department of Medicine

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