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Demo Programme


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 Funded PhD Programme (Students Worldwide)

About the Programme

The DNA-damage response (DDR) is underpinned by a complex set of signalling pathways involving interactions that are often regulated by post-translation modifications (PTMs). In most cases the physiological effects of these modifications are unknown but it has become clear that many act as molecular ‘switches', signalling the spatially and temporally appropriate of protein assemblies. Of the many known PTMs, phosphorylation is arguably the most important and abundant and we now know of several proteins and domains t are able to specifically ‘read' phosphorylated motif signatures in target proteins. Nonetheless, the range of interactions regulated in this way remains frustratingly unclea

This project seeks to address the generic problem of how to identify and match individual phosphorylation events to functional interactions that may be rather transient in nature, initially in the specific context the DDR. This will require a highly multi-disciplinary approach combining structural, chemical and synthetic phospho-interactome of a key DDR signalling component, Nbs1. The focus will be to generate engineered Nbs1 variants that are able to trap interacting phospho-proteins allowing more robust identification than has previously been possible, thus expanding our systems-level understanding of the intricacies of DDR signalling pathways and networks.

Applicants should have a strong background in biochemistry, and ideally a background in molecular biology and/or chemistry. They should have a commitment to research in biomedicine and hold or realistically expect to obtain at least an Upper Second Class Honours Degree in biochemistry.

Funding Notes

Cardiff University , School of Journalism, Media and Culture, supported by the ESRC Doctoral Training Partnership for Wales (Wales DTP), invites applications for PhD study in the pathway of Journalism and Democracy, with the possibility of being awarded a fully-funded ESRC DTP Studentship, to start in October 2021. Short-listed applicants will be invited to interview expected to take place in late February/early March 2021. After interview, a final short-list of applicants will be put to the ESRC Wales DTP Management Group Panel where final decisions will be made. Successful applicants can generally expect to hear by early April 2021
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